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Human Polyclonal DNTT Primary Antibody for WB - ABIN3043577
Tochinai, Ando, Suzuki, Suzuki, Nagata, Hata, Uchida, Kobayashi, Kado, Kaneko: Histopathological studies of microtubule disassembling agent-induced myocardial lesions in rats. in Experimental and toxicologic pathology : official journal of the Gesellschaft fu?r Toxikologische Pathologie 2013
Show all 9 Pubmed References
Human Polyclonal DNTT Primary Antibody for ICC, IF - ABIN4358323
Mann, Newberg, Black, Jones, Amaya-Manzanares, Guzman-Rojas, Kodama, Ward, Rust, van der Weyden, Yew, Waters, Leung, Rogers, Rogers, McNoe, Selvanesan, Navin, Jenkins, Copeland, Mann: Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq. in Nature biotechnology 2016
Human Polyclonal DNTT Primary Antibody for WB - ABIN4891886
Troshchynsky, Dzneladze, Chen, Sheng, Saridakis, Wu: Functional analyses of polymorphic variants of human terminal deoxynucleotidyl transferase. in Genes and immunity 2015
TdT expression was most prominent in thymus, pro- and mesonephros, the primary lymphoid organs in teleost fish and in spleen, intestine, and the tissue around the intestine.
Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.
Molecular dynamics simulations and structural analysis to decipher functional impact of a twenty residue insert in the ternary complex of mus musculus TdT isoform have been reported.
TdT is essential for the generation of the predominant higher-affinity DEX-responsive J558 clone
Production of M603-id antibody is TdT dependent, while generation of M167-id antibody is TdT independent.
onset of terminal deoxynucleotidyl transferase gene activation during T cell differentiation and thymic ontogeny
The role of this locus in autoantibody production in MRL/lpr mouse strain, and subsequent development of kidney disease.
tdt may be involved in learning and memory saving.
There is an observed decrease in the incidence of autoimmune disease, including absence of diabetes and decreased pancreatic infiltration in NOD TdT-deficient mice, and reduced glomerulonephritis and increased life span in MRL-Fas(lpr) TdT-deficient mice.
Structure-function analysis of proposed domains and motifs for known activity of TdT reveals nonessential role for tumor suppressor BRCA1 C-terminal (BRCT) domain and essential roles for second helix-hairpin-helix motif and entire C terminus of TdT.
third hypervariable region assumes for each immunoglobulin chain, with DNA polymerase (pol) lambda maintaining a large heavy chain junctional heterogeneity and pol mu ensuring a restricted light chain junctional variability
TdT plays a critical role in the magnitude and breadth of anti-viral T(CD8+) responses toward individual determinants
The role of TdT ensures enhanced diversity and selection of private T cell receptor repertoires and promotes optimal CD8-positive T cell immunity, both within individuals and across the species as a whole.
Data from one institution indicate that TdT-negative acute lymphoblastic leukemia (ALL) is not uncommon (14% of cases between 2005 and 2015) and that the lack of TdT and/or CD34 expression by flow cytometric analysis does not exclude the diagnosis of ALL.
TdT protein can be found in cells of epithelial origin and specifically sebaceous cells, both benign and malignant.
Structural basis for a new templated activity by terminal deoxynucleotidyl transferase and implications for V(D)J recombination have been described.
TdT-positive cells may be part of the inflammatory milieu in infant kidneys.
Absence of TdT expression identifies a subset of high-risk T-acute lymphoblastic leukemia/lymphoma that overlaps with, but is not identical to, the ETP leukemia, providing additional prognostic value.
Our study confirms that PAX5 and TdT expression can be expressed in a high percentage of Merkel cell carcinomas and so when positive are not diagnostic of lymphoblastic leukemia/lymphoma.
role in DNA repair
Overexpression of newly discovered alternatively spliced short or long human TdT isoforms greatly reduces the efficiency of recombination, which is reverted to normal levels by the simultaneous expression of both enzymes.
In spleen, appendix and branchial cleft cysts the range of TdT-positivity was 0-13, 0-96 and 0-6 TdT+ cells per high-power field.
The TdT binding, DNA binding and dimerization regions, and nuclear localization signal (NLS) in TdIF1, were identified.
In all seminoma cases investigated (10/10) as well as in two tumor-associated germ cell neoplasias in situ (2/2) the TdT staining intensity was variable but was often moderate to strong and restricted to the nucleus
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
, DNA nucleotidylexotransferase
, terminal deoxynucleotidyl transferase
, terminal addition enzyme
, terminal transferase
, deoxynucleotidyltransferase, terminal
, nucleosidetriphosphate:DNA deoxynucleotidylexotransferase
, terminal deoxyribonucleotidyltransferase