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Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs).
Efficiency of differentiation of Induced pluripotent stem cells to insulin (show INS Proteins) producing cells can be increased by concurrent expression of PDX1 (show PDX1 Proteins) and NKX6.1 during progenitor cells maturation.
NKX6.1 directly enhances the mRNA level of E-cadherin (show CDH1 Proteins) by recruiting BAF155 (show SMARCC1 Proteins) coactivator and represses that of vimentin (show VIM Proteins) and N-cadherin (show CDH2 Proteins) by recruiting RBBP7 (retinoblastoma binding protein 7 (show RBBP7 Proteins)) corepressor.
NKX6.1 is a factor for IL-6 (show IL6 Proteins)-regulated growth and tumor formation in basal-like breast cancer.
a significant relationship was observed between NKX6.1 and EMT (show ITK Proteins) marker expression levels, and NKX6.1 knockdown inhibited cell invasion, and overexpression of NKX6.1 promotes cell proliferation in vitro.
study evaluated the potential use of NKX6-1 as a diagnostic marker for well-differentiated neuroendocrine tumors
NKX6-1 reveals wide variations in methylation levels in normal control samples of cervical adenocarcinomas.
Mice transplanted with NKX6.1-low cells remained hyperglycemic throughout the 5-month post-transplant period whereas diabetes was reversed in NKX6.1-high recipients within 3 months.
MAFA (show KLRG1 Proteins), MAFB (show MAFB Proteins), NKX6.1, and PDX1 (show PDX1 Proteins) activity provides a gauge of islet beta cell function, with loss of MAFA (show KLRG1 Proteins) (and/or MAFB (show MAFB Proteins)) representing an early indicator of beta cell inactivity
Smooth muscle cells expressing nestin (show NES Proteins) and Nkx6.1 are the main cell population derived from culturing human spinal cord cells in adherent conditions with serum.
nkx6.1 regulates the alpha- and beta-cell formation in zebrafish by acting on the stem cells in the Islets of Langerhans.
In zebrafish, Nkx6.1 is expressed in early-born primary and later-born secondary motoneurons
Study shows that zebrafish primary motoneurons express two related transcription factors Nkx6.1 and Nkx6.2; in their absence, the CaP motoneuron subtype develops normally, whereas the MiP motoneuron subtype develops a interneuron-like morphology.
The results suggest that Nkx6.1 is involved in mid-hindbrain formation in Xenopus embryos, likely by modulating wnt1 (show WNT1 Proteins) expression.
Nkx6.1 and Nkx6.2 share overlapping expression domains in the ventral neural tube at neurula stages and later in the ventral part of developing hindbrain and spinal cord. Nkx6.3 (show NKX6-3 Proteins) is detected in the non-neural ectoderm.
Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord.
MAFA (show MAFA Proteins), MAFB (show MAFB Proteins), NKX6.1, and PDX1 (show PDX1 Proteins) activity provides a gauge of islet beta cell function, with loss of MAFA (show MAFA Proteins) (and/or MAFB (show MAFB Proteins)) representing an early indicator of beta cell inactivity
Over time, Nkx6.1-deficient beta cells acquired molecular characteristics of delta cells, revealing a molecular link between impaired beta cell functional properties and loss of cell identity.
Our findings establish Nkx6.1 as a beta (show SUCLA2 Proteins) cell programming factor and demonstrate that repression of alternative lineage programs is a fundamental principle by which beta cells are specified and maintained.
Data found direct binding of RBP (show RBP4 Proteins)-jkappa to the Nkx6.1 proximal promoter.
Results demonstrate that sustained Nkx6.1 overexpression in vivo does not stimulate beta-cell proliferation, expand beta-cell mass, or improve glucose metabolism in either normal or beta-cell-depleted pancreata.
Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.
Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1 (show POU4F1 Proteins)-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon.
Ependymal cells in adult spinal cord are derived from Nkx6.1+ ventral neural progenitor cells. Nkx6.1+ ependymal cells in adult mouse spinal cords may retain the proliferative property of neural stem cells.
Results demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration.
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004)
NK6 transcription factor related, locus 1
, NK6 homeobox 1
, NK homeo box, family 6, member A
, NK homeobox, family 6, A
, NK6 transcription factor homolog A
, homeobox protein NK-6 homolog A
, homeobox protein Nkx-6.1
, NK6 transcription factor related locus 1
, Drosophila NK transcription factor related, gene family 6, locus 1
, homeodomain transcription factor Nkx6.1