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anti-Mouse (Murine) SLC6A3 Antibodies:
anti-Human SLC6A3 Antibodies:
anti-Rat (Rattus) SLC6A3 Antibodies:
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Mouse (Murine) Monoclonal SLC6A3 Primary Antibody for ELISA, ICC - ABIN4354469
Johnson, Guptaroy, Lund, Shamban, Gnegy: Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. in The Journal of biological chemistry 2005
Show all 11 Pubmed References
Human Polyclonal SLC6A3 Primary Antibody for FACS, IF (cc) - ABIN733373
Ni, Hu, Ren, Luo, Li, Wan, Su: Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. in PLoS ONE 2013
Show all 3 Pubmed References
Golden Syrian Hamster Polyclonal SLC6A3 Primary Antibody for IHC (fro), IHC (p) - ABIN152593
Rodríguez, Uchida, Nakayama: Immunohistochemical changes of nigrostriatal tyrosine hydroxylase and dopamine transporter in the golden hamster after a single intrastriatal injection of 6-hydroxydopamine. in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2013
Show all 3 Pubmed References
Mouse (Murine) Monoclonal SLC6A3 Primary Antibody for ICC, IF - ABIN1169684
Cremona, Matthies, Pau, Bowton, Speed, Lute, Anderson, Sen, Robertson, Vaughan, Rothman, Galli, Javitch, Yamamoto: Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. in Nature neuroscience 2011
Show all 3 Pubmed References
Human Polyclonal SLC6A3 Primary Antibody for IHC - ABIN965973
Donovan, Vandenbergh, Perry, Bird, Ingersoll, Nanthakumar, Uhl: Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures. in Brain research. Molecular brain research 1995
Show all 6 Pubmed References
Mouse (Murine) Polyclonal SLC6A3 Primary Antibody for IHC - ABIN2690501
Varner, Jaquins-Gerstl, Michael: Enhanced Intracranial Microdialysis by Reduction of Traumatic Penetration Injury at the Probe Track. in ACS chemical neuroscience 2016
Show all 2 Pubmed References
Human Polyclonal SLC6A3 Primary Antibody for IHC (fro), WB - ABIN2473356
Mozley, Gur, Mozley, Gur: Striatal dopamine transporters and cognitive functioning in healthy men and women. in The American journal of psychiatry 2001
Human Polyclonal SLC6A3 Primary Antibody for IHC (fro), WB - ABIN2473357
Gaffaney, Vaughan: Uptake inhibitors but not substrates induce protease resistance in extracellular loop two of the dopamine transporter. in Molecular pharmacology 2004
Human Monoclonal SLC6A3 Primary Antibody for IHC (fro), WB - ABIN2473358
Miller, Staley, Heilman, Perez, Mash, Rye, Levey: Immunochemical analysis of dopamine transporter protein in Parkinson's disease. in Annals of neurology 1997
Show all 2 Pubmed References
DNA of the impulsive but not the calm subjects was methylated at one DAT SNP.
nitrative damage accumulates in midbrain neurons with age; The capacity of a dopamine neuron to accumulate more cytosolic DA, as inferred from DA transporter expression, is related to accumulation of nitrative damage
Two C-terminal motifs dictate synaptic localization of DAT-1.
Endogenous dopamine actions in C. elegans are tightly regulated by synaptic DAT-1.
loss of UNC-64/DAT-1 interactions leads to enhanced synaptic dopamine release
Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum.
Study generated a transgenic rat model that overexpresses the mouse DAT gene via pronuclear microinjection. These rats specifically exhibited behavioral and pharmaco-therapeutic phenotype of repetitive disorders. Together, findings suggest that the DAT rat model will constitute a valuable tool for studying the pathological role of DAT overexpression on neural systems relevant to relevant to neuropsychiatric disorders.
The findings of thuis study indicated that the DAT Val559 variant induces impulsivity behaviors that are dependent upon the reward context, with increased impulsive action observed when mice are required to delay responding for a reward.
These results suggest that DAT expression affects TH expression and phosphorylation largely in DA terminal field compartments.
These behavioral and molecular phenotypes indicate that a genetic-driven DAT hypofunction alters neurodevelopmental trajectories consistent with ADHD, but not with schizophrenia and bipolar disorders.
An exquisite microanatomical regulation of dopamine by the dopamine transporter was identified in striosomes relative to the matrix in the corpus striatum.
Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3.
This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation.
The sigma-1R deficiency through suppressing NR2B (show GRIN2B Antibodies) function and DAT expression can reduce MPTP (show PTPN2 Antibodies)-induced death of dopaminergic neurons and parkinsonism.
DAT gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 (show CA1 Antibodies) field of the hippocampus.
DAT-mediated dopamine uptake plays a role in the absorption and distribution of dopamine following intranasal administration
genetically determined differences in DAT1 and DRD2 (show DRD2 Antibodies) expression modulate functional consequences of sleep deprivation.
SLC6A3 gene moderates the relation between maternal history of maltreatment and infant emotion regulation.
The age-related reduction in striatal DAT density also predicted memory decline, suggesting that a relation between striatal functions and memory decline in aging is multifaceted.
genetic association studies in population of young adults in Columbia: Data suggest that genetic polymorphisms in DRD4 (show DRD4 Antibodies) and SLC6A3 are associated with overweight/obesity in the population studied; DRD4 (show DRD4 Antibodies) 4/4 genotype is associated with lower BMI and SLC6A3 10/10 genotype is associated with higher BMI. (DRD4 (show DRD4 Antibodies) = dopamine receptor D4 (show DRD4 Antibodies); SLC6A3 = solute carrier family 6 member 3)
Results indicate that chronic coffee consumption in Parkinson's disease (PD) patients was not associated with significant change in striatal DAT availability, even after taking into account potentially confounding factors that are probably related to dopaminergic neuron decline (age, sex, disease duration, and severity of PD), treatment, and coffee-related habit (cigarette smoking).
This is the first study to investigate the association of rs3910105 in SNCA [SNCA protein, human] with DAT [dopamine transporter] availability. rs3910105 had an effect on DAT availability, and the correlation between DAT availability and SNCA transcripts were significant in CT [computed tomography] genotypes of rs3910105.
Study describes an association between the 6R6R genotype of the intron 8 VNTR of the dopamine transporter (DAT1) gene and crack cocaine addiction.
From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmenta
Results show that Gbetagamma activation regulates DAT activity by increasing dopamine (DA) efflux, and suggests that Gbetagamma promotes an efflux-willing state of the transporter and that the activation of a GPCR (show NMUR1 Antibodies) can lead to a Gbetagamma-dependent DA efflux. Furthermore, the cellular responses that occur following activation of a Galphaq (show GNAQ Antibodies)-coupled receptor are the result of multiple signaling pathways mediated by Galpha (show SUCLG1 Antibodies)...
Findings demonstrate that histidine547 on hDAT plays a crucial role in stabilizing basal dopamine transport and Tat (show TAT Antibodies)-DAT interaction.
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
dopamine transporter variant II
, sodium-dependent dopamine transporter
, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
, sodium-dependent dopamine transporter-like
, DA transporter
, dopamine transporter 1
, solute carrier family 6 member 3
, solute carrier family 6, member 3