Browse our anti-GRB7 (GRB7) Antibodies

Mouse (Murine) Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

1. GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR-193.

2. Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.

3. The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation of kappa opioid receptor.

4. Grb7 is identified as an integral component of stress granules.

Human Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

1. It was identified that silencing of miR193a3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling.

2. MiR-193a-3p not only modulated GRB7 but also ERBB4.

3. Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer

4. data shows that GRB7 expression in invasive breast cancer correlates with markers of a more aggressive phenotype, including HER2 overexpression, a greater degree of HER2 amplification, ER negativity, and p53 positivity

5. The crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain.

6. Grb7 protein Ras-associating domain oligomerization has been reported.

7. Study provided a direct link between the signal adapter protein Grb7, anti-apoptotic protein Hax1 isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1-related apoptosis pathways mediated by Caspase3.

8. Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization.

9. Grb7 was found to be significantly related to the biological classification of breast cancer

10. apo Grb7 SH2 domain crystallized in the trigonal space group P63, whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21

11. The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2+ve cell types

12. Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton.

13. Data suggest that calmodulin controls Grb7-mediated cell migration.

14. Data propose the phosphorylation state of Grb7-SH2 domain tyrosine residues could control Grb7 dimerization, and dimerization may be an important regulatory step in Grb7 binding to RTKs such as erbB2.

15. GRB7 is a context-dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt.

16. propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS

17. A series of Grb7 SH2 domain-binding nonphosphorylated peptides in the yeast two-hybrid system, were identified.

18. GRB7 protein over-expression is an independent adverse prognostic factor in human breast cancer

19. Full-length Grb7 and Hax-1 interact in mammalian cells and Grb7 is tyrosine phosphorylated.

20. X-ray diffraction data were collected from crystals to 2.4A resolution for G7-18NATE in complex with its Grb7 SH2 domain.