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Human Polyclonal GRB7 Primary Antibody for ELISA, WB - ABIN249513
Margolis, Silvennoinen, Comoglio, Roonprapunt, Skolnik, Ullrich, Schlessinger: High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. in Proceedings of the National Academy of Sciences of the United States of America 1992
GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR (show MLXIP Antibodies)-193.
Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR (show EGFR Antibodies)-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
The adaptor Grb7 links netrin-1 (show NTN1 Antibodies) signaling to regulation of mRNA translation of kappa opioid receptor (show OPRK1 Antibodies).
Grb7 is identified as an integral component of stress granules.
Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer
data shows that GRB7 expression in invasive breast cancer correlates with markers of a more aggressive phenotype, including HER2 (show ERBB2 Antibodies) overexpression, a greater degree of HER2 (show ERBB2 Antibodies) amplification, ER negativity, and p53 (show TP53 Antibodies) positivity
The crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain.
Grb7 protein Ras-associating domain oligomerization has been reported.
Study provided a direct link between the signal adapter protein (show TOLLIP Antibodies) Grb7, anti-apoptotic protein Hax1 (show HAX1 Antibodies) isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1 (show HAX1 Antibodies)-related apoptosis pathways mediated by Caspase3.
Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization.
Grb7 was found to be significantly related to the biological classification of breast cancer
apo (show C9orf3 Antibodies) Grb7 SH2 domain crystallized in the trigonal space group P63 (show RPE65 Antibodies), whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21 (show CDKN1A Antibodies)
The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2 (show ERBB2 Antibodies)+ve cell types
Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton.
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
growth factor receptor-bound protein 7
, growth factor receptor-bound protein 7-like
, GRB7 adapter protein
, Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7)
, epidermal growth factor receptor GRB-7
, growth factor receptor binding protein GRB7