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Human Polyclonal HGS Primary Antibody for IP, WB - ABIN4317267
Buchanan, Schalm, Maniatis: Proteolytic processing of protocadherin proteins requires endocytosis. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Polyclonal HGS Primary Antibody for ELISA, WB - ABIN563957
Calabia-Linares, Robles-Valero, de la Fuente, Perez-Martinez, Martín-Cofreces, Alfonso-Pérez, Gutierrez-Vázquez, Mittelbrunn, Ibiza, Urbano-Olmos, Aguado-Ballano, Sánchez-Sorzano, Sanchez-Madrid et al.: Endosomal clathrin drives actin accumulation at the immunological synapse. ... in Journal of cell science 2011
Human Monoclonal HGS Primary Antibody for IF, RNAi - ABIN563958
McLeod, Zhou, Li, Wang, He: The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7R? surface expression. in Journal of immunology (Baltimore, Md. : 1950) 2011
Human Polyclonal HGS Primary Antibody for IHC (p), IHC - ABIN251318
Kobayashi, Tanaka, Asao, Miura, Kyuuma, Semura, Ishii, Sugamura: Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. in The Journal of biological chemistry 2005
Human Polyclonal HGS Primary Antibody for ICC, IF - ABIN4317269
Brockmeyer, Paster, Pepper, Tan, Trudgian, McGowan, Fu, Gascoigne, Acuto, Salek: T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. in The Journal of biological chemistry 2011
Results demonstrate the existence of crosstalk between beta-catenin signaling and HGS in two different types of cancer (hepatoblastoma and colorectal).
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM (show STAM Antibodies)) and the complex formation with STAM (show STAM Antibodies) promotes its endosomal dissociation.
we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).
the role for tumoral c-Met expression or sMet/HGF (show HGF Antibodies) levels as upfront selection criterion or predictive biomarkers deserve further study in this emerging area of therapeutic focus in RCC (show XRCC1 Antibodies)
Hrs tyrosine phosphorylation detected upon EGF (show EGF Antibodies)-stimulation.
Hrs inhibits HIV-1 production by inhibiting citron kinase (show CIT Antibodies)-mediated exocytosis.
ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin (show BST2 Antibodies) down-regulation.
Plasma hepatocyte growth factor (show HGF Antibodies) is associated with periampullary cancer.
hSpry2 binds to the endocytic regulatory protein, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and blocks intracellular signal propagation.
The HRS domain required for merlin (show NF2 Antibodies) binding is narrowed to a region (residues 470-497) containing the predicted coiled-coil domain whereas the major domain responsible for HRS growth suppression is distinct (residues 498-550).
structure of a complex of Hrs-UIM and ubiquitin at 1.7-A resolution [ubiquitin]
Findings find that Hrs is indispensable for the autophagic clearance of neurodegeneration-related proteins and for the survival of hippocampal neurons in mammals. In particular, the work provides the novel insight that the loss of Hrs results in insufficient autophagic clearance and enhanced ER stress, thereby triggering JNK (show MAPK8 Antibodies) activation and subsequent apoptotic and necroptotic neuronal cell death.
HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function.
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
A new mechanism to modify BMP signaling by Hgs during early mouse development.
Hrs is a master molecule that controls in part the degradation of STAM1 (show STAM Antibodies) and the accumulation of ubiquitinated proteins
Data suggest that Hrs regulates the KGFR (show FGFR2 Antibodies) degradative pathway, but not its juxtanuclear recycling transport, and that Hrs recruitment to the receptor, but not its ligand-induced phosphorylation, could be required for its function.
Nedd4-2 (show NEDD4L Antibodies) induces binding of ENaC (show SCNN1A Antibodies) to Hrs, which mediates the sorting decision between ENaC (show SCNN1A Antibodies) degradation and recycling.
Peptidergic versus nonpeptidergic specification depends on a balance between HGF (show HGF Antibodies)-Met signaling and Runx1 (show RUNX1 Antibodies) extinction/maintenance in primary nociceptive neurons.
Src (show SRC Antibodies) phosphorylates Hrs in vitro & in vivo. Hrs is phosphorylated in Src (show SRC Antibodies)-, Yes- & Fyn (show FYN Antibodies)-negative cells. 10-20% is phosphorylated after EGF (show EGF Antibodies) stimulation at multiple tyrosines in different parts of Hrs by several kinases downstream of the EGF receptor (show EGFR Antibodies).
These results reveal that ESCRT-0 (ESCRT-0 components stam (show STAM Antibodies) and hrs)mutants inhibit EGFR (show EGFR Antibodies) signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
Hrs is dispensable for cytokinesis. Finally, it was found that although Drosophila Hrs does not localize at acrosome, the other endosomal markers--Rab4, Rab7, and Rab11--are detected at the organelle.
Drosophila epithelia lacking Hrs and Stam (show STAM Antibodies), accumulate Notch (show NOTCH1 Antibodies) and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch (show NOTCH1 Antibodies) signaling activation.
Hrs mediates Smo trafficking in the late endosome by not only promoting Smo ubiquitination but also blocking Smo phosphorylation.
these data support a model in which Ubpy (show USP8 Antibodies) plays a dual role in both cargo deubiquitylation and the ESCRT-0 subunit Hrs stability during development.
show that the endosomal proteins Myopic (Mop (show OPN4 Antibodies)) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are required for the activation of the Toll (show TLR4 Antibodies) signaling pathway.
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
human growth factor-regulated tyrosine kinase substrate
, protein pp110
, HGF-regulated tyrosine kinase substrate
, SNAP-25-interacting protein Hrs-2
, hepatocyte growth factor-regulated tyrosine kinase substrate
, hepatocyte growth factor regulated tyrosine kinase
, hepatocyte growth factor regulated tyrosine kinase substrate
, hepatocyte growth-factor-regulated substrate
, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog