anti-Human PTPRJ antibody for Blocking Reagent

Recommended PTPRJ Antibody (supplied by: Log in to see )

Antigen
Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) Antibodies
  • DEP-1
  • PTPRJ
  • CD148
  • DEP1
  • HPTPeta
  • R-PTP-ETA
  • SCC1
  • AI450271
  • BET
  • Byp
  • PTPbeta2
  • Ptpb2
  • RPTPJ
  • Scc-1
  • Scc1
  • protein tyrosine phosphatase, receptor type, J
  • protein tyrosine phosphatase, receptor type J
  • Ptprj
  • PTPRJ
  • EUBREC_2762
Reactivity
Human
126
24
19
1
1
Host
Mouse
67
64
2
Clonality
Monoclonal
Conjugate
This PTPRJ antibody is conjugated to PE
11
7
6
6
4
4
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA
59
54
35
32
19
13
11
11
8
5
3
1
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Catalog No. ABIN2663041
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General

Antigen Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) Antibodies
Reactivity Human
(126), (24), (19), (1), (1)
Host Mouse
(67), (64), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This PTPRJ antibody is conjugated to PE
(11), (7), (6), (6), (4), (4), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA
(59), (54), (35), (32), (19), (13), (11), (11), (8), (5), (3), (1)
Pubmed 6 references available
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Product Details anti-PTPRJ Antibody

Target Details PTPRJ Application Details Handling References for anti-PTPRJ antibody (ABIN2663041) Images
Purification The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Clone A3
Isotype IgG1 kappa
Plasmids, Primers & others

Target Details PTPRJ

Product Details anti-PTPRJ Antibody Application Details Handling References for anti-PTPRJ antibody (ABIN2663041) Images back to top
Antigen
Alternative Name CD148 (PTPRJ Antibody Abstract)
Background CD148, a receptor-like protein tyrosine phosphatase also known as human protein tyrosine phosphatase-eta (HPTP-eta) or density-enhanced protein tyrosine phosphatase-1 (DEP-1), is involved in signal transduction in leucocytes and is thought to contribute to mechanisms of cellular differentiation. In lymphoid organs, CD148 was found to be widely expressed on B and T cells, granulocytes, macrophages, certain dendritic cells as well as mature thymocytes. The cellular level of CD148 was increased after in vitro activation of peripheral blood leucocytes. CD148 as a leucocyte activation marker and may be involved in the regulation of T cell activation. Leucocytes expressing CD148 are significantly upregulated in inflamed tissues and that a subset of these cells co-expresses the activation marker CD25. In non-lymphoid tissues, CD148 was found to be present on many epithelial cell types with glandular and/or endocrine differentiation as well as on fibrocytes, melanocytes and Schwann cells. Among non-hematopoietic cells, CD148 is expressed by characteristic types of epithelial and non-epithelial cells. Downregulation of CD148 might promote dedifferentiation and autonomous growth of such cells in malignant tumors.
Pathways EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling

Application Details

Product Details anti-PTPRJ Antibody Target Details PTPRJ Handling References for anti-PTPRJ antibody (ABIN2663041) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-PTPRJ Antibody Target Details PTPRJ Application Details References for anti-PTPRJ antibody (ABIN2663041) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-PTPRJ antibody (ABIN2663041)

Product Details anti-PTPRJ Antibody Target Details PTPRJ Application Details Handling Images back to top
Background publications

Whiteford, Xian, Chaussade, Vanhaesebroeck, Nourshargh, Couchman: "Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148." in: Molecular biology of the cell, Vol. 22, Issue 19, pp. 3609-24, 2011

Lin, Weiss: "The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling." in: The Journal of cell biology, Vol. 162, Issue 4, pp. 673-82, 2003

Autschbach, Palou, Mechtersheimer, Rohr, Pirotto, Gassler, Otto, Schraven, Gaya: "Expression of the membrane protein tyrosine phosphatase CD148 in human tissues." in: Tissue antigens, Vol. 54, Issue 5, pp. 485-98, 2000

Tangye, Phillips, Lanier, de Vries, Aversa: "CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 7, pp. 3249-55, 1998

Tangye, Liu, Aversa, Phillips, de Vries: "Identification of functional human splenic memory B cells by expression of CD148 and CD27." in: The Journal of experimental medicine, Vol. 188, Issue 9, pp. 1691-703, 1998

Tangye, Wu, Aversa, de Vries, Lanier, Phillips: "Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 8, pp. 3803-7, 1998

Images

Product Details anti-PTPRJ Antibody Target Details PTPRJ Application Details Handling References for anti-PTPRJ antibody (ABIN2663041) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) antibody (PE) (ABIN2663041) anti-Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) antibody (PE)