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AgRP is not associated with changes in hunger or satiety, and can change without corresponding changes in leptin (show LEP Proteins). This suggests that AgRP may not be involved in the episodic control of appetite and the release of AgRP may involve signals other than leptin (show LEP Proteins).
data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (show MC4R Proteins)), pro-opiomelanocortin (POMC (show POMC Proteins)), apolipoprotein E (APOE (show APOE Proteins)) and agouti-related protein (AGRP) with obesity in the North Indian population.
CSF (show CSF2 Proteins) AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects.
human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor (show MC4R Proteins)
Variations in genes AGRP, CPE (show CPE Proteins), GHRL (show GHRL Proteins), GLP1R (show GLP1R Proteins), HTR2A, NPY1R (show NPY1R Proteins), NPY5R (show NPY5R Proteins), SOCS3 (show SOCS3 Proteins) and STAT3 (show STAT3 Proteins) showed modest associations with BMI in European Americans.
Elevations in AgRP also favor the diagnosis of ectopic ACTH (show POMC Proteins) syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker.
AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients.
Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men.
Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin (show LEP Proteins) concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance.
The findings are consistent with the idea that, during metabolic deficiency, AgRP signaling contributes to infertility by inhibiting Kiss1 (show KISS1 Proteins) neurons.
POMC (show POMC Proteins) and AgRP neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (show KISS1 Proteins)(ARC (show NOL3 Proteins)) neurons in male mice
P2Y6 (show P2RY6 Proteins) signaling in AgRP neurons is involved in the onset of obesity-associated hyperphagia.
These results identify SK3 (show KCNN3 Proteins) as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY (show NPY Proteins) neural activities and animals' feeding behavior and energy metabolism.
It was concluded that a small population of neuroendocrine cells in the adrenal medulla, and the arcuate nucleus of the hypothalamus, express AgRP and neuropeptide Y (show NPY Proteins) and are functionally involved in the systemic response to fasting.
These findings indicate that the relevance of AgRP to POMC (show POMC Proteins) neuron GABA connectivity depends on the state of AgRP neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
CRFR1 (show CRHR1 Proteins), in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY (show NPY Proteins) neurons in mice.
Data show that agouti-related protein (AgRP)-glucocorticoid receptor (show NR3C1 Proteins) knockout (GR-/-) mice are resistant to diet-induced obesity.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp) and neuropeptide Y (Npy (show NPY Proteins)) gene expression similarly in Ghrelin (show GHRL Proteins)+/+, Ghrelin (show GHRL Proteins)-/-, ghrelin receptor Ghsr (show GHSR Proteins)+/+, and Ghsr (show GHSR Proteins)-/- mice.
(Nle4, d-Phe7)-alphaMSH (show POMC Proteins) (NDP (show NDP Proteins)-alphaMSH (show POMC Proteins)) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor (show MC4R Proteins)
Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP (show NDP Proteins)-alphaMSH (show POMC Proteins)-induced cortisol production through its antagonistic properties towards MSH (show POMC Proteins) at the level of MC4-R (show MC4R Proteins)
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
, orexigenic neuropeptide
, agouti related protein
, agouti related protein homolog (mouse)