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genetic association studies in pediatric population in Japan: Data suggest that mutations in ACAN (aggrecan), FGFR3 (fibroblast growth factor receptor-3 (show FGFR3 Proteins)), or GHRHR (growth- hormone-releasing-hormone receptor (show GHRHR Proteins)) are associated with idiopathic short stature in the population studied.
In bicuspid aortic valve disease, there was a significant reduction of aggrecan expression in bicuspid aortic valve.
Overexpression of miR (show MLXIP Proteins)-3150a-3p decreased ACAN expression in nucleus pulposus cells, whereas inhibition of miR (show MLXIP Proteins)-3150a-3p increased ACAN expression. In addition, ACAN expression was negatively correlated with intervertebral disc degeneration (IDD (show COL9A3 Proteins)) grade. The reduction of ACAN expression induced by the upregulation of miR (show MLXIP Proteins)-3150a-3p might participate in the development of IDD (show COL9A3 Proteins).
Our study demonstrated that altered levels of ADAMTS-1 (show ADAMTS1 Proteins) and aggrecan may have a partial role in the etiopathogenesis of Polycystic ovary syndrome (PCOS), and ADAMTS-1 (show ADAMTS1 Proteins) could be a predictive marker for implantation success in PCOS patients.
ACAN mutation is a relative common cause of familial severe short stature
Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera.
single nucleotide variants of ACAN and their haplotypes are associated with the severity of lumbar disc herniation.
Four of 29 small for gestational age children with advanced bone age had an ACAN gene mutation (13.8%). Mutations were related to additional characteristics: midface hypoplasia, joint problems, and broad great toes.
SNVs of candidate genes in ACAN metabolic pathway are associated with severity of Lumbar disc degeneration and Modic changes in patients with chronic mechanical low back pain.
Heterozygous aggrecan mutations result in a phenotypic spectrum ranging from mild and proportionate short stature to a mild skeletal dysplasia with disproportionate short stature and brachydactyly.
Kartogenin effectively increased the expression of Col (show HDAC1 Proteins) II and aggrecan in hNPCs and slowed the degeneration of intervertebral discs stimulated by IL-1b (show IL1B Proteins) and TNF-a (show TNF Proteins)
Acan mRNA and protein was reduced by 50% in AgcCre/Cre mouse model of dwarfism. Analysis of gene expression indicates impaired differentiation of chondrocyte in hyaline cartilage of AgcCre/Cre mice.
As the primary site of agc1-deficiency is neuronal, this explains the lack of accumulation of brain lactate in agc1-deficiency in humans and mice.
Aggrecan has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival.
Aggrecan, link protein (show HAPLN1 Proteins) and TN-R (show TNR Proteins) were identified to be essential for the neuroprotective properties of the perineuronal net.
the subsequent presentation of aggregan from ECM (show MMRN1 Proteins) leads to CD4 (show CD4 Proteins)(+) T-cell activation and effector cell formation.
Runx3 (show RUNX3 Proteins) positively regulates aggrecan expression and suggest that its function is more limited to cartilage development than to bone.
The role of ADAMTS5 (show ADAMTS5 Proteins) in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.
role of ADAMTS5 (show ADAMTS5 Proteins) in dermal repair through CD44 (show CD44 Proteins)-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1 (show TGFB1 Proteins)) signaling
CSGalNAcT-1 (show CSGALNACT1 Proteins) is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.
Data show that expression of mRNAs for aggrecan, collagen type II, and versican (show Vcan Proteins) were significantly effected by the intervention.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (show ADAMTS5 Proteins) (aggrecanase (show ADAMTS4 Proteins)) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.
Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.
aggrecanase (show ADAMTS4 Proteins) activity (a) is responsible for early TNFalpha (show TNF Proteins)-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue.
aggrecan plays a protective role in preventing degradation of collagen fibrils
Changes in aggrecan and type II collagen (show COL2A1 Proteins) promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.
AGC1 mRNA expression level was upregulated by multidirectional articular motion.
Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).
keratan sulphate in the interglobular domain of pig aggrecan has a microstructure that is distinct from keratan sulphate in the keratan sulphate-rich region
Aggrecan synthesis in intervertebral disc cells is stimulated by E-cadherin (show CDH1 Proteins).
he dwarf (show POU1F1 Proteins) Miniature Shetland pony had the homozygous mutant genotype C/C of the ACAN:g.94370258G>C variant and the normal parents were heterozygous G/C. An unaffected full sib and 3/5 unaffected half-sibs were heterozygous G/C for the ACAN:g.94370258G>C variant. In summary, we could demonstrate a dwarf (show POU1F1 Proteins) phenotype in a miniature pony breed perfectly associated with a missense mutation within the ACAN gene.
At 0.1 and 1 microM concentrations, LE135 weakly but significantly increased chondral morphology scores, compared to untreated controls. Lack of aggrecan expression and lack of increased CII:CI ratio, compared to controls, did not affect chondrogenesis.
degenerative suspensory ligament desmitis ligaments showed a 15-fold increase in aggrecan compared to normal
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
aggrecan core protein
, cartilage-specific proteoglycan core protein
, chondroitin sulfate proteoglycan core protein 1
, large aggregating proteoglycan
, aggrecan 1
, aggrecan, structural proteoglycan of cartilage
, aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
, aggrecan epidermal growth factor-like domain-1
, chondroitin sulfate proteoglycan core protein
, cartilage aggregating proteoglycan
, chondroitin sulfate proteoglycan 1
, large aggregating proteoglycan, antigen
, aggrecan core protein-like
, aggrecan interglobular domain