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high levels of both Claudin-2 and Afadin in primary tumors were associated with poor disease-specific survival, relapse-free survival, lung-specific relapse, and liver-specific relapse
CLDN2 may have a role regulating tissue-specific physiological properties in tight junctions in UC.
the accumulation of DXR into spheroids was enhanced by claudin-2 knockdown, resulting in a reduction in cell viability. We suggest that claudin-2 may be a novel therapeutic target in lung adenocarcinoma, because claudin-2 knockdown increased the accumulation of anticancer agents in cancer cells and spheroids.
integration of claudin-2, occludin and ZO-1 is necessary for maintaining the function of the proximal tubular epithelium.
these findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA-dependent repression of claudin-2
Low CLDN2 expression is associated with Lung Cancer metastasis.
results reveal that IL-22 increases intestinal epithelial permeability by upregulating Claudin-2 expression through the JAK/STAT pathway
In summary, we demonstrate that TCPTP protects the intestinal epithelial barrier by restricting STAT-induced claudin-2 expression.
The cation channel-forming tight junction protein claudin-2 was shown to permit the paracellular passage of water through its pore.
suggest that epigenetic inhibitors suppress the abnormal proliferation of lung adenocarcinoma cells highly expressing claudin-2
Data show that alterations in myosin light chain kinase activity, claudin-15 and claudin-2 expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).
hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells.
The claudin-2 expression increased in tumor necrosis factor alpha (TNF-alpha) Treated Caco-2 cell monolayers.
We conclude that Claudin-2 expression is significantly associated with bile acid receptors VDR and TGR5 expression. Our studies identify a novel role of a tight junction protein in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma.
The authors conclude that claudin-2 forms gated paracellular channels.
Association of claudin2 (rs7057398) polymorphism with idiopathic recurrent acute pancreatitis and progression of the disease to chronic pancreatitis.
Genetic variants in CLDN2 and MORC4 genes were associated with chronic pancreatitis in Indian patients.
The current study reveals an important and novel mechanism for VDR by regulation of epithelial barriers.
Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.
Pan-inhibition of SFK signaling pathways elevated Claudin-2 expression levels in breast cancer cells. Loss of Yes or Fyn induces Claudin-2 expression; whereas, diminished Lyn levels impairs Claudin-2 expression in breast cancer cells.
claudin-2-null mice conserve sodium to the same extent as WT mice, even during profound dietary sodium depletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick ascending limb of Henle
The tight junction patch clamp technique indicated mouse claudin-2 ion channel opening events in MDCK cells
findings reveal a critical albeit complex role of claudin-2 in intestinal homeostasis by regulating epithelial permeability, inflammation and proliferation
Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow.
IL-6 modulation of intestinal TJ permeability was regulated by JNK activation of AP-1 and AP-1 activation of claudin-2 gene
this study set out to map out all the pore-lining residues of claudin-2 by comprehensive cysteine-scanning mutagenesis of the entire first extracellular loop (ECL1).
The capacity of non-AQP1-dependent transcellular proximal fluid reabsorption (PFR) is sufficient to be maintained in AQP1- and claudin-2-doubly deficient knockout mice.
These results suggest that the ERK pathway positively regulates claudin-2 protein expression and claudin-2 is involved in lowering TER in CMT93-II cells.
Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.
cingulin is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2.
Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane
STAT6 regulates claudin-2 induction in oxazolone (OXA) colitis; claudin-2 staining is increased in wild-type OXA mice but not in STAT6-deficient animals.
Claudin-2 is expressed at the variety of epithelial tissues in the coclea of inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus.
during breast cancer liver metastasis, claudin-2 shifts from acting within tight-junctional complexes to functioning as an adhesion molecule between breast cancer cells and hepatocytes.
we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages
Claudin-2 expression was abnormal at the plasma membrane of intestinal epithelial cells in adherent-invasive Escherichia coli-infected CEABAC10 mice.
Claudin-2 promoter activity is increased by IL-6 in a MEK/ERK and PI3K-dependent manner
Claudin 2 is indispensable for paracellular sodium permeability in the small intestine.
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
, integral membrane protein claudin-2