Browse our DIO1 Proteins (DIO1)

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.

• iodothyronine deiodinase 1 (DIO1)
• type I iodothyronine deiodinase-like (LOC100231867)
• deiodinase, iodothyronine, type I (Dio1)
• deiodinase, iodothyronine type 1 L homeolog (dio1.L)
• iodothyronine deiodinase 1 (dio1)

• 5DI protein
• cb685 protein
• D1 protein
• Deio1 protein
• DIOI protein
• Show all synonym aliases
• ITDI1 protein
• TXDI1 protein
• zgc:92323 protein

DIOI , thyroxine deiodinase type I (selenoprotein) , type 1 DI , type I iodothyronine deiodinase , type-I 5'-deiodinase , thyroxine deiodinase, type I , 5DI , thyroxine deiodinase type 1 , Type 1 DI , Type-I 5'-deiodinase , deiodinase, iodothyronine, type I , type 1 deiodinase