Browse our DIO1 Proteins (DIO1)

Full name:: Deiodinase, Iodothyronine, Type I Proteins (DIO1)

On www.antibodies-online.com are 8 Deiodinase, Iodothyronine, Type I (DIO1) Proteins from 5 different suppliers available. Additionally we are shipping DIO1 Antibodies (36) and DIO1 Kits (24) and many more products for this protein. A total of 70 DIO1 products are currently listed.

Synonyms:: 5DI, cb685, D1, Deio1, DIOI, ITDI1, TXDI1, zgc:92323

list all proteins	Gene Name	GeneID	UniProt
	DIO1	1733	P49895
	DIO1	25430	P24389
	DIO1	13370	Q61153
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DIO1 Proteins (DIO1) by Origin

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Relevant Pathways for DIO1 Proteins

Hormone Activity

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Human Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

Multivariate linear regression analysis revealed that the DIO1 (show DIDO1 Proteins) concentration and FT3 level were not associated with the concentration of serum 8-Isoprostane
The expression of DIO1 (show DIDO1 Proteins) on mRNA/protein levels in the depressive disorder patients was reduced in comparison to the control subjects.
wW observed that the DIO1 (show DIDO1 Proteins) rs2235544 SNP modified the association between exposure to some of the organochlorine compounds (OCs) (specifically HCB and PCB153) and maternal thyroid hormone (show PTH Proteins) levels. These results strengthen the hypothesis that the deiodinase enzymes play a role in explaining the disruption of thyroid hormones in relation to exposure to OCs.
data supports the notion that suppressed DIO1 (show DIDO1 Proteins) expression and changes in local availability of thyroid hormones might favor a shift from a differentiated to a more proliferation-prone state of cancer tissues and cell lines
results indicated that LXRalpha (show NR1H3 Proteins) plays a specific and important role in activation of TH by regulating D1, and that LXRalpha (show NR1H3 Proteins) binds to and regulates the hDIO1 promoter, competing with TRbeta (show TXNRD2 Proteins) on specific sequences within the promoter.
The DIO1 (show DIDO1 Proteins) gene is related to the depression.
Functional variants within the DIO1 (show DIDO1 Proteins) gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions.
All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 (show DIDO1 Proteins) function in HepG2 cells.
Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.
The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium.

Mouse (Murine) Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

Reductions in Dio1 expression reduce the expression of ApoA-I (show APOA1 Proteins) in a 3,5,3'-triiodothyronine-/thyroid hormone (show PTH Proteins) response element-independent manner.
Systemic changes in thyroid hormone (show PTH Proteins) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type4 and type3 in tissues and their enhanced metabolism by deiodinase D3.
Results demonstrate changes in D1 activity in white adipose tissue under conditions of changing adiposity, and a stimulatory effect of leptin (show LEP Proteins) on D1 activity in the tissue.
A decreased hepatic D1 activity could be the biochemical basis of some of the abnormal thyroid parameters observed in cystic fibrosis (show S100A8 Proteins)
The type 1 deiodinase (D1) is an important source of Triiodothyronine in the euthyroid state.
HNF4alpha (show HNF4A Proteins) regulates thyroid hormone (show PTH Proteins) homeostasis through transcriptional regulation of the Dio1 gene with GATA4 (show GATA4 Proteins) and KLF9 (show KLF9 Proteins)

Pig (Porcine) Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

Zebrafish Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

This study investigated deiodinase 1 (Dio1), deiodinase 2 (Dio2 (show DIO2 Proteins)), and deiodinase 3 (Dio3 (show DIO3 Proteins)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.

DIO1 Protein Profile

Protein Summary

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.

Alternative names and synonyms associated with DIO1

iodothyronine deiodinase 1 (DIO1)
type I iodothyronine deiodinase-like (LOC100231867)
deiodinase, iodothyronine, type I (Dio1)
deiodinase, iodothyronine type 1 L homeolog (dio1.L)
iodothyronine deiodinase 1 (dio1)

5DI protein
cb685 protein
D1 protein
Deio1 protein
DIOI protein
ITDI1 protein
TXDI1 protein
zgc:92323 protein

Protein level used designations for DIO1

DIOI , thyroxine deiodinase type I (selenoprotein) , type 1 DI , type I iodothyronine deiodinase , type-I 5'-deiodinase , thyroxine deiodinase, type I , 5DI , thyroxine deiodinase type 1 , Type 1 DI , Type-I 5'-deiodinase , deiodinase, iodothyronine, type I , type 1 deiodinase

GENE ID	SPECIES
1733	Homo sapiens
100231867	Taeniopygia guttata
25430	Rattus norvegicus
13370	Mus musculus
395940	Gallus gallus
403635	Canis lupus familiaris
414380	Sus scrofa
100101570	Oryctolagus cuniculus
493798	Felis catus
733447	Xenopus laevis
799937	Danio rerio

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