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Gene body methylation of noncoding RNA genes was observed and among these microRNA genes were prominent. Of particular note, observed only in hyperphenylalaninemic animals, was hypomethylation of miRNA genes within the imprinted Dlk1 (show DLK1 Proteins)-Dio3 locus on chromosome 12.
Dio3-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2 (show DIO2 Proteins)-/- mice, cone function was largely normal but deletion of Dio2 (show DIO2 Proteins) in Dio3-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival.
The marked phenotypic abnormalities observed in the D3-deficient mouse, including perinatal mortality, growth retardation, and central hypothyroidism in adult animals, require expression of MCT8 (show MCT8 Proteins), confirming the interdependent relationship between the TH transport into cells and the deiodination processes.
The brain-specific (show CALY Proteins) miR (show MLXIP Proteins)-379/miR (show MLXIP Proteins)-410 gene cluster at the imprinted Dlk1 (show DLK1 Proteins)-Dio3 domain is implicated in several aspects of brain development and function.
DNA methylation (show HELLS Proteins) regulates genomic imprinted DLK1 (show DLK1 Proteins)-Dio3 miRNAs in autoimmune lupus
identify the molecular regulators involved in the recruitment of AFF3 to gDMRs and provide mechanistic insight into the requirement of AFF3 at an enhancer for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1 (show DLK1 Proteins)-Dio3 locus
Dppa3 (show DPPA3 Proteins) has a critical role in generation of fully reprogrammed iPS (show SLC27A4 Proteins) cells and maintenance of Dlk1 (show DLK1 Proteins)-Dio3 imprinting
Gtl2((-/+)) teratomas have decreased expression of 28 miRNAs encoded by the Dlk1 (show DLK1 Proteins)-Dio3 domain
This study provides the spatiotemporal expression and dynamic changes of lncRNAs from Dlk1-Dio3 imprinted region in mouse preimplantation stage embryos and offers insight into the potential mechanisms responsible for Gtl2 activation.
The existence of unidentified epigenetic determinants of tissue-specific Dio3 imprinting.
No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.
In neonatal skin, DIO3 exhibited a high degree of monoallelic expression from the paternal allele.
Presence and subcellular location of D3 in human neutrophils for the first time and propose a model, in which D3 plays a role in the bacterial killing capacity of neutrophils either through generation of iodide for the myeloperoxidase (show MPO Proteins) system or through modulation of intracellular Thyroid hormone (show PTH Proteins) bioavailability.
MAPK (show MAPK1 Proteins) and SHH (show SHH Proteins) pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma
Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.
the microRNA cluster at the Dlk1 (show DLK1 Proteins)-Dio3 locus is upregulated in lung adenocarcinoma
[review] D3 polymorphisms show no relationship with inter-individual variation in serum thyroid hormone (show PTH Proteins) parameters.
Overall, the data suggest that active expression of the DLK1 (show DLK1 Proteins)-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs.
the imprinted DLK1 (show DLK1 Proteins)-DIO3 locus is regulated by noncoding RNA IPW in an induced pluripotent stem cell model of Prader-Willi syndrome
Data indicate that Na+/I- symporter and type 3 iodothyronine deiodinase genes are expressed in term placenta and amniotic membrane.
Reviewed are the microRNAs within the DLK1 (show DLK1 Proteins)-DIO3 genomic region, their role in controlling tissue homeostasis and in the pathogenesis of some human diseases, mostly cancer, when aberrantly expressed. [review]
The imprinted gene DIO3 is a candidate gene for litter size in pigs
DIO3 gene polymorphism was significantly associated with almost all fat deposition and carcass traits.
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
type III iodothyronine deiodinase
, Type 3 DI
, Type-III 5'-deiodinase
, type 3 iodothyronine deiodinase
, deiodinase, iodothyronine, type III
, gene 15
, type 3 deiodinase
, iodothyronine 5-deiodinase type III
, type 3 DI
, type-III 5'-deiodinase
, deiodinase, iodothyronine, type 3
, iodothyronine deiodinase, placental type
, thyroxine deiodinase type III (selenoprotein)
, type 3 iodothyronine selenodeiodinase
, type-III 5' deiodinase
, iodothyronine deiodinase type III