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Results demonstrate that DIO3 is essential for normal aggression and maternal behaviors, and indicate that abnormal local regulation of thyroid hormone (show PTH Proteins) action in the brain may contribute to the social deficits associated with neurodevelopmental disorders.
Functional analysis revealed that ground-state miRNAs embedded in the Dlk1 (show DLK1 Proteins)-Dio3 locus (miR (show MLXIP Proteins)-541-5p, miR (show MLXIP Proteins)-410-3p, and miR (show MLXIP Proteins)-381-3p) promoted pluripotency via inhibition of multi-lineage differentiation and stimulation of self-renewal
Results indicate that basal cell carcinoma cells constitute an example in which the thyroid hormone (show PTH Proteins) signal is finely tuned by the concerted expression of opposite-acting deiodinases. The dual regulation of Dio2 (show DIO2 Proteins) and Dio3 expression plays a critical role in cell cycle progression and cell death by influencing cyclin D1 (show CCND1 Proteins)-mediated entry into the G1-S phase.
Gene body methylation of noncoding RNA genes was observed and among these microRNA genes were prominent. Of particular note, observed only in hyperphenylalaninemic animals, was hypomethylation of miRNA genes within the imprinted Dlk1 (show DLK1 Proteins)-Dio3 locus on chromosome 12.
Dio3-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2 (show DIO2 Proteins)-/- mice, cone function was largely normal but deletion of Dio2 (show DIO2 Proteins) in Dio3-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival.
The marked phenotypic abnormalities observed in the D3-deficient mouse, including perinatal mortality, growth retardation, and central hypothyroidism in adult animals, require expression of MCT8 (show MCT8 Proteins), confirming the interdependent relationship between the TH transport into cells and the deiodination processes.
The brain-specific (show CALY Proteins) miR (show MLXIP Proteins)-379/miR (show MLXIP Proteins)-410 gene cluster at the imprinted Dlk1 (show DLK1 Proteins)-Dio3 domain is implicated in several aspects of brain development and function.
DNA methylation (show HELLS Proteins) regulates genomic imprinted DLK1 (show DLK1 Proteins)-Dio3 miRNAs in autoimmune lupus
identify the molecular regulators involved in the recruitment of AFF3 to gDMRs and provide mechanistic insight into the requirement of AFF3 at an enhancer for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1 (show DLK1 Proteins)-Dio3 locus
Dppa3 (show DPPA3 Proteins) has a critical role in generation of fully reprogrammed iPS (show SLC27A4 Proteins) cells and maintenance of Dlk1 (show DLK1 Proteins)-Dio3 imprinting
No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.
The expression of DIO3 on mRNA/protein levels in the depressive disorders patients was increased in comparison to the control subjects.
The expression of piRNAs encoded at DLK1 (show DLK1 Proteins)-DIO3 enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting lung cancer patient outcome.
In neonatal skin, DIO3 exhibited a high degree of monoallelic expression from the paternal allele.
Presence and subcellular location of D3 in human neutrophils for the first time and propose a model, in which D3 plays a role in the bacterial killing capacity of neutrophils either through generation of iodide for the myeloperoxidase (show MPO Proteins) system or through modulation of intracellular Thyroid hormone (show PTH Proteins) bioavailability.
MAPK (show MAPK1 Proteins) and SHH (show SHH Proteins) pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma
Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.
the microRNA cluster at the Dlk1 (show DLK1 Proteins)-Dio3 locus is upregulated in lung adenocarcinoma
[review] D3 polymorphisms show no relationship with inter-individual variation in serum thyroid hormone (show PTH Proteins) parameters.
Overall, the data suggest that active expression of the DLK1 (show DLK1 Proteins)-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs.
the imprinted DLK1 (show DLK1 Proteins)-DIO3 locus is regulated by noncoding RNA IPW in an induced pluripotent stem cell model of Prader-Willi syndrome
The imprinted gene DIO3 is a candidate gene for litter size in pigs
DIO3 gene polymorphism was significantly associated with almost all fat deposition and carcass traits.
An allele-specific expression analysis-based SNP method revealed that DIO3 and DIO3OS genes exhibited monoallelic expression in the eight tissues, indicating that DIO3 and DIO3OS are imprinted in cattle.
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
type III iodothyronine deiodinase
, Type 3 DI
, Type-III 5'-deiodinase
, type 3 iodothyronine deiodinase
, deiodinase, iodothyronine, type III
, gene 15
, type 3 deiodinase
, iodothyronine 5-deiodinase type III
, type 3 DI
, type-III 5'-deiodinase
, deiodinase, iodothyronine, type 3
, iodothyronine deiodinase, placental type
, thyroxine deiodinase type III (selenoprotein)
, type 3 iodothyronine selenodeiodinase
, type-III 5' deiodinase
, iodothyronine deiodinase type III