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Human FNDC5 Protein expressed in Wheat germ - ABIN1354283
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
Show all 3 Pubmed References
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
FNDC5 mRNA expression in skeletal muscle and circulating irisin concentration relatively to exercise mode, intensity, frequency and duration and the characteristics of the sample used
Serum concentrations of irisin are elevated in post-myocardial infarction patients with increased risk for adverse cardiovascular events.
Acute high-intensity interval exercise decreased irisin levels and increased myostatin (show MSTN Proteins) levels.
Glucocorticoid receptor (show NR3C1 Proteins) positively regulates transcription of FNDC5 in the liver.
This study finds that soccer matches performed different workout times have strong stimulatory effects on irisin levels in all subjects but nesfatin-1 (show NUCB2 Proteins) response varied among the subjects and it did not change significantly in afternoon match.
Results show that Irisin concentration in umbilical cord blood was found to be associated with preterm birth (PTB (show PTBP1 Proteins)). On the other hand, no differences in maternal blood irisin levels between mothers with preterm and term deliveries were established.
Irisin concentrations do not predict risk of developing diabetes prospectively
serum irisin levels were significantly lower in patients with psoriasis, and associated with serum lipid levels and disease activity; these results can be interpreted that irisin is involved in the disease pathogenesis of patients with psoriasis in relation to metabolic dysregulation
This study show the serum irisin levels had significant positive correlation with seizure severity Chalfont score and the duration of epilepsy.
clinical evidence of the association between serum irisin and vascular calcification in HD patients
Findings demonstrated that one bout of both uphill and downhill exercise trainings as well as 8 weeks of training could increase the expression of PGC-1alpha and FNDC5 genes in the muscle tissues and the UCP1 (show UCP1 Proteins) gene in the subcutaneous adipose tissue.
Our study has indicated that irisin (FNDC5) possesses important anti-oxidant and anti-inflammatory properties and may protect cells from the damage induced by ROS (show ROS1 Proteins) under inflammatory conditions by activating of the Nrf2 (show NFE2L2 Proteins)/HO-1 (show HMOX1 Proteins) pathway.
FNDC5 attenuated Oxidized low density lipoprotein-induced AMPK (show PRKAA1 Proteins) deactivation, hepatic stellate cells activation, connective tissue growth factor (show CTGF Proteins) and transforming growth factor-beta upregulation and extracellular matrix deposition in mouse hepatic stellate cells.
the coordinated expression of FNDC5 and PGC-1alpha may contribute to the increased levels of plasma irisin after exercise.
Irisin(Fndc5) increases myogenic differentiation and myoblast fusion via activation of IL6 (show IL6 Proteins) signaling.
FNDC5 is overexpressed in skeletal muscle and adipose tissue of insulin (show INS Proteins) resistant high fat-fed mice.
This study for the first time showed that adipocytes are directly affected by irisin (Fndc5) and provides an evidence on anti-inflammatory action of irisin on fat cells.
Mstn (show MSTN Proteins) regulates Fndc5/Irisin expression and secretion through a novel miR (show MLXIP Proteins)-34a-dependent post-transcriptional mechanism; loss of Mstn (show MSTN Proteins) in mice leads to the increased Fndc5/Irisin expression, which contributes to the browning of white adipocytes
The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin (show INS Proteins) biosynthesis and glucose-stimulated insulin (show INS Proteins) secretion, and beta-cell apoptosis are reported.
these results indicate that unaltered endogenous irisin is required to maintain food intake in zebrafish.[irisin]
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein