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Human FNDC5 Protein expressed in Wheat germ - ABIN1354283
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
Show all 3 Pubmed References
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity.
irisin was significantly higher in obese than in control children, and was inversely correlated with Acrp30 and high molecular weight (HMW) oligomers; inverse correlation between Irisin and Acrp30 and, more significantly, between Irisin and HMW oligomers suggests that the two cytokines are closely connected
Irisin is an oxidative stress marker and a metabolic protective hormone.
Mild cold exposure increased vasoconstriction with a drop in in-the-ear temperature and these were related. Greater irisin was related to a greater fasting fat oxidation in the absence of shivering
Activation of the nuclear receptor constitutive androstane receptor (show NR1I3 Proteins) (CAR) induced FNDC5 mRNA expression in the liver.
HCC (show FAM126A Proteins)-liver tissue over-expressed FNDC5/Irisin in association with gene expression of mediators involved in lipogenesis, inflammation and cancer, suggesting a possible protective role of the hormone from the liver damage.
The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin (show INS Proteins) biosynthesis and glucose-stimulated insulin (show INS Proteins) secretion, and beta-cell apoptosis are reported.
Irisin regulates the number and function of endothelial progenitor cells via the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/eNOS (show NOS3 Proteins) pathway in mouse model of diabetes mellitus.
there is a correlation between sport performance, insulin (show INS Proteins) sensitivity, and irisin levels
results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS (show ROS1 Proteins)-NLRP3 (show NLRP3 Proteins) inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke.
Mstn (show MSTN Proteins) regulates Fndc5/Irisin expression and secretion through a novel miR (show MLXIP Proteins)-34a-dependent post-transcriptional mechanism; loss of Mstn (show MSTN Proteins) in mice leads to the increased Fndc5/Irisin expression, which contributes to the browning of white adipocytes
Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD without significant fibrosis.
Irisin improved endothelial function by modulating HO-1 (show HMOX1 Proteins)/ adiponectin axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 Proteins) degradation.
The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (show PRKAA1 Proteins)/mTOR (show FRAP1 Proteins) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.
This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (show ROS1 Proteins)) overproduction, which could suggest its potential anti-inflammatory properties.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Proteins).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
these results indicate that unaltered endogenous irisin is required to maintain food intake in zebrafish.[irisin]
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein