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Human FNDC5 Protein expressed in Wheat germ - ABIN1354283
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
Show all 3 Pubmed References
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
serum irisin levels were lower in Peritoneal Dialysis patients with Protein Energy Wasting than those of the patients without PEW
Data suggest that decreased irisin levels are associated with metabolic syndrome in prepubertal children; irisin may be a biomarker for metabolic syndrome in prepubertal children. This study was conducted in Seoul, Republic of Korea.
Findings revealed that irisin may play a critical role in the IL-6 (show IL6 Proteins)-induced epithelialmesenchymal transition of osteosarcoma cells via the STAT3 (show STAT3 Proteins)/Snail (show SNAI1 Proteins) signaling pathway.
FNDC5 gene interactions with candidate genes FOXOA3 and APOE (show APOE Proteins)
Irisin is negatively associated with serum testosterone in apopulation sample of men with Metabolic syndrome.
Irisin replenishment in mCaROCK1 mice partially reversed insulin (show INS Proteins) resistance.
Suggest that irisin exerts beneficial effect on mood in COPD (show ARCN1 Proteins) patients, possibly by inducing the expression of BDNF (show BDNF Proteins) in brain areas associated with reward-related processes involved in by depression.
Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity.
Obese children had significantly higher irisin and lower oxytocin levels than the healthy controls.
We determined FNDC5 polymorphisms frequencies in the Israeli population and demonstrated that maternal and neonatal FNDC5 rs726344 polymorphism is significantly associated with increased risk for preterm birth. Women bearing FNDC5 rs726344 GG genotype had 2.18 fold higher chance to deliver on time compared to AG and AA genotypes.Neonatal carrying FNDC5 rs726344 GG genotype had 2.24 fold higher chance to be born on time.
FNDC5 attenuated Oxidized low density lipoprotein-induced AMPK (show PRKAA1 Proteins) deactivation, hepatic stellate cells activation, connective tissue growth factor (show CTGF Proteins) and transforming growth factor-beta upregulation and extracellular matrix deposition in mouse hepatic stellate cells.
the coordinated expression of FNDC5 and PGC-1alpha may contribute to the increased levels of plasma irisin after exercise.
Irisin(Fndc5) increases myogenic differentiation and myoblast fusion via activation of IL6 (show IL6 Proteins) signaling.
FNDC5 is overexpressed in skeletal muscle and adipose tissue of insulin (show INS Proteins) resistant high fat-fed mice.
This study for the first time showed that adipocytes are directly affected by irisin (Fndc5) and provides an evidence on anti-inflammatory action of irisin on fat cells.
Mstn (show MSTN Proteins) regulates Fndc5/Irisin expression and secretion through a novel miR (show MLXIP Proteins)-34a-dependent post-transcriptional mechanism; loss of Mstn (show MSTN Proteins) in mice leads to the increased Fndc5/Irisin expression, which contributes to the browning of white adipocytes
The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin (show INS Proteins) biosynthesis and glucose-stimulated insulin (show INS Proteins) secretion, and beta-cell apoptosis are reported.
Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD without significant fibrosis.
Irisin improved endothelial function by modulating HO-1 (show HMOX1 Proteins)/ adiponectin axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 Proteins) degradation.
these results indicate that unaltered endogenous irisin is required to maintain food intake in zebrafish.[irisin]
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein