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Cow (Bovine) Polyclonal ABCC2 Primary Antibody for WB - ABIN610784
Cockcroft, Thomas, Fensome, Geny, Cunningham, Gout, Hiles, Totty, Truong, Hsuan: Phospholipase D: a downstream effector of ARF in granulocytes. in Science (New York, N.Y.) 1994
Show all 5 Pubmed References
Results show that the response to treatment depended of the variability in genes engaged in drugs' transport ABCC2 c.-24C>T and ABCB1 (show ABCB1 Antibodies) p.Ser893Ala/Thr (show TRH Antibodies) and in DNA repair machinery ERCC2 (show ERCC2 Antibodies) p.Lys751Gln.
Self-inhibition of the MRP2-dependent secretion of MTX (show MTX1 Antibodies) is a plausible explanation for the time-dependent PKs of this drug.
SMS (show SMS Antibodies) regulates the expression and function of drug transporters P-gp (show ABCB4 Antibodies) and MRP2.
genetic association studies in a population in France: Data that SNPs in ABCC2 are associated with regulation of secretion of endogenous organic anions; the 3 SNPs investigated (-24C>T, exon 1, rs717620; c.3972C>T, exon 28, rs3740066; c.1249G>A, exon 10, rs2273697) are associated with differential excretion of 35 of the 108 metabolites analyzed.
BCRP and MRP2 can mediate elimination of ochratoxin A from cells, reducing OTA toxicity.
Four SNPs within the APOE (show APOE Antibodies) cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1 (show SORT1 Antibodies)/PSRC1 (show PSRC1 Antibodies) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80
We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL (show LIPA Antibodies)/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2.
In the present review we focus on the role of MRP2 in the apical membrane of the enterocytes, as an important component of this intestinal barrier, as well as on its regulation and provide a detailed compilation of significant contributions demonstrating that MRP2 expression and function vary under relevant physiological and pathophysiological conditions
ABCC2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
Meta-analysis. The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs.
Biotinylation and streptavidin pull-down assays confirmed that CAL (show S100A11 Antibodies) dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL (show S100A11 Antibodies) interacts with Mrp2 and is a negative regulator of Mrp2 expression.
Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.
In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.
Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 (show ABCC1 Antibodies) and Mrp2, in WT cells but not in metallothionein (show MT Antibodies)-null cells.
hepatic transporters Ntcp (show SLC10A1 Antibodies) and Mrp2 are downregulated in rodent models of necrotizing enterocolitis
Both Abcc2 and Abcc3 (show ABCC3 Antibodies) significantly influenced the PK properties of MTX (show MTX1 Antibodies).
hyperosmotic cholestasis is triggered by a NADPH oxidase (show NOX1 Antibodies)-driven reactive oxygen species formation that mediates Fyn (show FYN Antibodies)-dependent retrieval of the Mrp2 and Bsep (show ABCB11 Antibodies) from the canalicular membrane, which may involve an increased cortactin (show CTTN Antibodies) phosphorylation.
Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan
In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism.
Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
ATP-binding cassette sub-family C member 2
, canalicular multidrug resistance protein
, canalicular multispecific organic anion transporter 1
, multidrug resistance-associated protein 2
, multidrug resistance protein 2
, ATP-binding cassette, sub-family C (CFTR/MRP), member 2
, calicular multispecific organic anion transporter
, multidrug resistance associated protein 2