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IDO Products

(Indoleamine 2,3-Dioxygenase (IDO))
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].

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Featured IDO Categories

IDO Antibodies

High quality antibodies with extensive validation data.

IDO ELISA Kits

Reliable ELISA kits for a wide range of species.

IDO Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IDO Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7433768
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7426307
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN5013734
Quantity 100 μL
Datasheet Datasheet

Recommended IDO ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (10)
  • (6)
Cat. No. ABIN6574282
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (6)
Cat. No. ABIN6730945
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956720
Quantity 96 tests
Datasheet Datasheet

Recommended IDO Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
Cat. No. ABIN6239816
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN4371986
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN4371989
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our IDO products

Albejante, Kunz, Ferreira, Júnior, de Almeida, Bacigalupo, Matheus, Dalboni, Camacho, Dellê: "Proteinuria is Associated with Urinary Loss of Cubilin and Vitamin D-Binding Protein in Patients with Preeclampsia." in: Scientific reports, Vol. 10, Issue 1, pp. 3956, (2020) (PubMed).

Guastella, Michelhaugh, Klinger, Fadel, Kiousis, Ali-Fehmi, Kupsky, Juhász, Mittal: "Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors." in: Journal of neuro-oncology, Vol. 139, Issue 2, pp. 239-249, (2019) (PubMed).

Duda, Curzytek, Kubera, Connor, Fagan, Basta-Kaim, Trojan, Papp, Gruca, Budziszewska, Leśkiewicz, Maes, Lasoń: "Interaction of the immune-inflammatory and the kynurenine pathways in rats resistant to antidepressant treatment in model of depression." in: International immunopharmacology, Vol. 73, pp. 527-538, (2019) (PubMed).

Guastella, Michelhaugh, Klinger, Kupsky, Polin, Muzik, Juhász, Mittal: "Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma." in: Molecular imaging, Vol. 15, (2016) (PubMed).

Cheung, Sampayo-Escobar, Green, Moore, Mohapatra, Mohapatra: "Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity via Interferon Beta and Indoleamine-2,3-Dioxygenase." in: PLoS ONE, Vol. 11, Issue 10, pp. e0163709, (2016) (PubMed).

Miles, Miller, Folkvord, Kimball, Chamanian, Meditz, Arends, McCarter, Levy, Rakasz, Skinner, Connick: "Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection." in: Nature communications, Vol. 6, pp. 8608, (2016) (PubMed).

Barathan, Gopal, Mohamed, Ellegård, Saeidi, Vadivelu, Ansari, Rothan, Ravishankar Ram, Zandi, Chang, Vignesh, Che, Kamarulzaman, Velu, Larsson, Kamarul, Shankar: "Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes." in: Apoptosis : an international journal on programmed cell death, (2015) (PubMed).

Gorchs, Hellevik, Bruun, Camilio, Al-Saad, Stuge, Martinez-Zubiaurre: "Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation." in: Frontiers in oncology, Vol. 5, pp. 87, (2015) (PubMed).

Bosnyák, Kamson, Guastella, Varadarajan, Robinette, Kupsky, Muzik, Michelhaugh, Mittal, Juhász: "Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas." in: Neuro-oncology, Vol. 17, Issue 9, pp. 1284-92, (2015) (PubMed).

Han, Chen, Yang, Jiang, Gu, Liu, Lin, Pan, Yu, Jiang, Zhou, Cao: "Human CD14+ CTLA-4+ regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma." in: Hepatology (Baltimore, Md.), Vol. 59, Issue 2, pp. 567-79, (2014) (PubMed).

Synonyms and alternative names related to IDO

indoleamine 2,3-dioxygenase 1 (IDO1), indoleamine 2,3-dioxygenase 1 (Ido1), IDO, Ido, IDO-1, INDO, Indo

Protein level used designations for IDO

  • indolamine 2,3 dioxygenase
  • indole 2,3-dioxygenase
  • indoleamine-pyrrole 2,3-dioxygenase
  • IDO-1
  • indoleamine-pyrrole 2,3 dioxygenase
  • indoleamine 23-dioxygenase
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