Browse our Prohibitin 2 Proteins (PHB2)

Full name:: Prohibitin 2 Proteins (PHB2)

On www.antibodies-online.com are 9 Prohibitin 2 (PHB2) Proteins from 5 different suppliers available. Additionally we are shipping Prohibitin 2 Antibodies (143) and Prohibitin 2 Kits (7) and many more products for this protein. A total of 168 Prohibitin 2 products are currently listed.

Synonyms:: ATPHB2, AU044498, Bap, Bap-37, bap37, Bcap27, Bcap37, DKFZp469N1310, F21M11.21, F21M11_21, p22, phb2, PNAS-141, prohibitin 2, prohibitin2, REA, wu:fc28c08, xphb2, zgc:73150

list all proteins	Gene Name	GeneID	UniProt
	PHB2	11331	Q99623
	PHB2	12034	O35129
Rat PHB2	PHB2	114766	Q5XIH7
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Prohibitin 2 Proteins (PHB2) by Origin

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Relevant Pathways for Prohibitin 2 Proteins

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Top referenced Prohibitin 2 Proteins

Human Prohibitin 2 Protein expressed in Wheat germ - ABIN1314863 : Lacombe, Mangé, Jarlier, Bascoul-Mollevi, Rouanet, Lamy, Maudelonde, Solassol: Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers. in International journal of cancer. Journal international du cancer 2013 (PubMed)

More Proteins for Prohibitin 2 Interaction Partners

Human Prohibitin 2 (PHB2) interaction partners

the present study suggested that PHB2 may promote Prostate cancer cell migration by inhibiting the expression of AKT2 (show AKT2 Proteins). These results provide information regarding the role of PHB2 in Prostate cancer migration and malignancy
Taken together, the results indicate that PHB2 plays a central role in p21 (show CDKN1A Proteins) upregulation following GGCT (show GGCT Proteins) knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21 (show CDKN1A Proteins).
analysis of LGALS3, PHB2, MUC1, and GK2 expression with CA15-3 in early-stage breast cancer
Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Proteins) and BIM (show BCL2L11 Proteins) upregulation.
REA modulates cross talk among multiple cell types in the uterine tissue and host background, serving as a brake on the estradiol-ER axis and restraining multiple aspects that contribute to the pathologic progression of endometriosis.
BIG3 (show WDR5 Proteins) may block the KPNAs (KPNA1 (show KPNA1 Proteins), KPNA5 (show KPNA5 Proteins), and KPNA6 (show KPNA6 Proteins)) binding region(s) of PHB2.
results show that PHB2 binds to the ligand binding domain of ERalpha (show ESR1 Proteins) with a conformational change in the helix 12 of ERalpha (show ESR1 Proteins)
Functional analysis of selected regulated proteins revealed that knockdown of HNRPD (show HNRNPD Proteins), PHB2 and UB2V2 (show UBE2V2 Proteins) can increase HCMV replication, while knockdown of A4 and KSRP (show KHSRP Proteins) resulted in decreased HCMV replication.
These results demonstrate that estradiol upregulates REA expression and recruits REA via ERalpha (show ESR1 Proteins) to the EREs on the RORgammaT promoter region, thus inhibiting RORgammaT expression and Th17 differentiation.
BIG3 (ARFGEF3) is predicted to interact with its partner PHB2 through an ARM-type alpha-helical structure.

Mouse (Murine) Prohibitin 2 (PHB2) interaction partners

Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Proteins) and BIM (show BCL2L11 Proteins) upregulation.
REA modulates cross talk among multiple cell types in the uterine tissue and host background, serving as a brake on the estradiol-ER axis and restraining multiple aspects that contribute to the pathologic progression of endometriosis.
CARL can suppress mitochondrial fission and apoptosis by targeting miR (show MLXIP Proteins)-539 and PHB2.
These results demonstrate that estradiol upregulates REA expression and recruits REA via ERalpha (show ESR1 Proteins) to the EREs on the RORgammaT promoter region, thus inhibiting RORgammaT expression and Th17 differentiation.
results suggest that PHB2 is a crucial mitochondrial regulator for homeostasis and lineage-specific differentiation of ES cells.
Loss of PHB2 impairs the stability of OPA1, affects mitochondrial ultrastructure, and induces the perinuclear clustering of mitochondria in hippocampal neurons
REA physiologically restrains endometrial stromal cell decidualization, controlling the timing and magnitude of decidualization to coordinate uterine differentiation with concurrent embryo development that is essential for implantation and fertility.
PHB1 (show PHB Proteins) and PHB2 are critical mediators in promoting 3T3-L1 adipocyte differentiation and may be the potential targets for obesity therapies
Optimal uterine development and functional activities require the normal gene dosage of REA, with partial or complete deletion resulting in hyperresponsiveness or underresponsiveness to hormone and subfertility or infertility, respectively.
Serine phosphorylation of PHB2 by CaMK IV (show CAMK4 Proteins) relieves its inhibition on MEF2 (show MEF2C Proteins).

Prohibitin 2 (PHB2) Protein Profile

Protein Summary

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity).

Alternative names and synonyms associated with Prohibitin 2 (PHB2)

prohibitin 2a (phb2a)
prohibitin 2 (PHB2)
prohibitin 2 (phb2)
prohibitin 2 S homeolog (phb2.S)
prohibitin 2 (Phb2)

ATPHB2 protein
AU044498 protein
Bap protein
Bap-37 protein
bap37 protein
Bcap27 protein
Bcap37 protein
DKFZp469N1310 protein
F21M11.21 protein
F21M11_21 protein
p22 protein
phb2 protein
PNAS-141 protein
prohibitin 2 protein
prohibitin2 protein
REA protein
wu:fc28c08 protein
xphb2 protein
zgc:73150 protein

Protein level used designations for Prohibitin 2 Proteins (PHB2)

B-cell receptor-associated protein 37 , prohibitin 2 , Prohibitin-2 , B-cell associated protein , B-cell receptor-associated protein BAP37 , D-prohibitin , prohibitin-2 , repressor of estrogen receptor activity , B-cell receptor associated protein 37

GENE ID	SPECIES
324421	Danio rerio
451805	Pan troglodytes
549305	Xenopus (Silurana) tropicalis
839228	Arabidopsis thaliana
100172520	Pongo abelii
11331	Homo sapiens
446470	Xenopus laevis
771124	Gallus gallus
486716	Canis lupus familiaris
515363	Bos taurus
12034	Mus musculus
114766	Rattus norvegicus

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Show all Prohibitin 2 Proteins (PHB2) with Pubmed References

Human Prohibitin 2 (PHB2) interaction partners

Mouse (Murine) Prohibitin 2 (PHB2) interaction partners

Protein Summary

Alternative names and synonyms associated with Prohibitin 2 (PHB2)

Protein level used designations for Prohibitin 2 Proteins (PHB2)