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Human Prohibitin 2 Protein expressed in Wheat germ - ABIN1314863
Lacombe, Mangé, Jarlier, Bascoul-Mollevi, Rouanet, Lamy, Maudelonde, Solassol: Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers. in International journal of cancer. Journal international du cancer 2013
Taken together, the results indicate that PHB2 plays a central role in p21 (show CDKN1A Proteins) upregulation following GGCT (show GGCT Proteins) knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21 (show CDKN1A Proteins).
analysis of LGALS3, PHB2, MUC1, and GK2 expression with CA15-3 in early-stage breast cancer
Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Proteins) and BIM (show BCL2L11 Proteins) upregulation.
REA modulates cross talk among multiple cell types in the uterine tissue and host background, serving as a brake on the estradiol-ER axis and restraining multiple aspects that contribute to the pathologic progression of endometriosis.
BIG3 (show WDR5 Proteins) may block the KPNAs (KPNA1 (show KPNA1 Proteins), KPNA5 (show KPNA5 Proteins), and KPNA6 (show KPNA6 Proteins)) binding region(s) of PHB2.
results show that PHB2 binds to the ligand binding domain of ERalpha (show ESR1 Proteins) with a conformational change in the helix 12 of ERalpha (show ESR1 Proteins)
Functional analysis of selected regulated proteins revealed that knockdown of HNRPD (show HNRNPD Proteins), PHB2 and UB2V2 (show UBE2V2 Proteins) can increase HCMV replication, while knockdown of A4 and KSRP (show KHSRP Proteins) resulted in decreased HCMV replication.
These results demonstrate that estradiol upregulates REA expression and recruits REA via ERalpha (show ESR1 Proteins) to the EREs on the RORgammaT promoter region, thus inhibiting RORgammaT expression and Th17 differentiation.
BIG3 (ARFGEF3) is predicted to interact with its partner PHB2 through an ARM-type alpha-helical structure.
Data indicate that the up-regulated expression of prohibitin (show PHB Proteins) promoted acute promyelocytic leukemia (show PML Proteins) cell line NB4-R1 cell apoptosis.
CARL can suppress mitochondrial fission and apoptosis by targeting miR (show MLXIP Proteins)-539 and PHB2.
results suggest that PHB2 is a crucial mitochondrial regulator for homeostasis and lineage-specific differentiation of ES cells.
Loss of PHB2 impairs the stability of OPA1, affects mitochondrial ultrastructure, and induces the perinuclear clustering of mitochondria in hippocampal neurons
REA physiologically restrains endometrial stromal cell decidualization, controlling the timing and magnitude of decidualization to coordinate uterine differentiation with concurrent embryo development that is essential for implantation and fertility.
PHB1 (show PHB Proteins) and PHB2 are critical mediators in promoting 3T3-L1 adipocyte differentiation and may be the potential targets for obesity therapies
Optimal uterine development and functional activities require the normal gene dosage of REA, with partial or complete deletion resulting in hyperresponsiveness or underresponsiveness to hormone and subfertility or infertility, respectively.
Serine phosphorylation of PHB2 by CaMK IV (show CAMK4 Proteins) relieves its inhibition on MEF2 (show MEF2C Proteins).
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity).
B-cell receptor-associated protein 37
, prohibitin 2
, B-cell associated protein
, B-cell receptor-associated protein BAP37
, repressor of estrogen receptor activity
, B-cell receptor associated protein 37