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|Antigen||Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) Antibodies|
|Conjugate||This AGT antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-AGT AntibodyTarget Details AGT Application Details Handling References for anti-AGT antibody (ABIN360211) Images
|Specificity||This antibody reacts to AGT.|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human AGT.|
Target Details AGTProduct Details anti-AGT Antibody Application Details Handling References for anti-AGT antibody (ABIN360211) Images back to top
|Alternative Name||Angiotensinogen (AGT Antibody Abstract)|
|Background||AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in AGT gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in AGT gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.Synonyms: AGT, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensin IV, Angiotensin-1, Angiotensin-2, Angiotensin-3, Angiotensin-4, SERPINA8, Serpin peptidase inhibitor, clade A, member 8|
|Gene ID||183, 9606|
|Pathways||JAK-STAT Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity|
Application DetailsProduct Details anti-AGT Antibody Target Details AGT Handling References for anti-AGT antibody (ABIN360211) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-AGT Antibody Target Details AGT Application Details References for anti-AGT antibody (ABIN360211) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-AGT antibody (ABIN360211)Product Details anti-AGT Antibody Target Details AGT Application Details Handling Images back to top
Gürkan, Emingil, Saygan, Atilla, Köse, Baylas, Berdeli: "Angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitis." in: Archives of oral biology, Vol. 54, Issue 4, pp. 337-44, 2009
Vickers, Hales, Kaushik, Dick, Gavin, Tang, Godbout, Parsons, Baronas, Hsieh, Acton, Patane, Nichols, Tummino: "Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 14838-43, 2002
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