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|Antigen||Interleukin-6 Receptor (IL6R) Antibodies|
|Epitope||AA 1-365 Alternatives|
|Conjugate||This IL-6 Receptor antibody is un-conjugated Alternatives|
Cell Culture (CC), Immunofluorescence (IF), Immunofluorescence (fixed cells) (IF/ICC)
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Product Details anti-IL-6 Receptor AntibodyTarget Details IL-6 Receptor Application Details Handling Images
|Specificity||Human IL-6R / CD126|
|Characteristics||This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126, ABIN2002778 NP_000556.1, Met1-Pro365,. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.|
|Purification||purified by Protein A affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Human IL-6R / CD126 protein (ABIN2002778)|
Target Details IL-6 ReceptorProduct Details anti-IL-6 Receptor Antibody Application Details Handling Images back to top
|Alternative Name||IL6R (IL6R Antibody Abstract)|
|Background||Interleukin 6 receptor subunit alpha, also known as IL6R1, CD126, and IL6Ra, is a type I transmembrane cytokine receptor and lacks a tyrosine/kinase domain within the cytoplasmic region, unlike other growth factor receptors. The IL6 receptor is composed of two different subunits, IL6R that binds IL6 with low affinity, and ubiquitously expressed Glycoprotein 130 (gp130) which acts as a common signal-transducing receptor and binds the IL-6/IL-6R complex with high affinity. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis. It has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases.|
|Pathways||JAK-STAT Signaling, Autophagy, Growth Factor Binding|
Application DetailsProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling Images back to top
ELISA(Cap): 0.5-4 μg/mL In a sandwich ELISA, it can be used as capture antibody.
ICC/IF: 10-25 μg/mL
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|
ImagesProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling back to top