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|Antigen||Interleukin 2 Receptor, gamma (IL2RG) Antibodies|
|Epitope||AA 23-254 Alternatives|
|Conjugate||This IL2RG antibody is un-conjugated Alternatives|
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Neutralization (Neut)
|3 references available|
|Supplier||Log in to see|
Product Details anti-IL2RG AntibodyTarget Details IL2RG Application Details Handling References for anti-IL2RG antibody (ABIN4899740) Images
|Specificity||Detects human Common gamma Chain/IL-2 R gamma in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R alpha , rhIL-2 R beta , rhIL-15 R alpha , recombinant mouse IL-2 R gamma , or recombinant canine IL-2 R alpha is observed. In Western blots, approximately 80 % cross-reactivity with recombinant human IL-2 R beta , 50 % cross-reactivity with rhIL-15 R alpha and recombinant mouse IL-2 R alpha , and no cross-reactivity with rhIL-2 R alpha is observed.|
|Purification||Protein A or G purified from hybridoma culture supernatant|
|Sterility||0.2 μm filtered|
|Endotoxin Level||<0.10 EU per 1 μg of the antibody by the LAL method.|
|Immunogen||S. frugiperda insect ovarian cell line Sf21-derived recombinant human Common gamma Chain/IL-2 gamma , Leu23-Asn254, Accession # P31785|
Target Details IL2RGProduct Details anti-IL2RG Antibody Application Details Handling References for anti-IL2RG antibody (ABIN4899740) Images back to top
|Alternative Name||IL2RG (IL2RG Antibody Abstract)|
|Background||Alternative Names: CD132, CD132 antigen, CIDX, combined immunodeficiency, X-linked, common cytokine receptor gamma chain, common gamma-chain, cytokine receptor common subunit gamma, gamma(c), IL-2 R gamma, IL-2 receptor subunit gamma, IL2R gamma, IL-2R subunit gamma, IL2RG, IL-2RG, IMD4, interleukin 2 receptor, gamma, Interleukin-2 receptor subunit gamma, p64, SCIDX, SCIDX1, severe combined immunodeficiency|
|Pathways||JAK-STAT Signaling, Growth Factor Binding|
Application DetailsProduct Details anti-IL2RG Antibody Target Details IL2RG Handling References for anti-IL2RG antibody (ABIN4899740) Images back to top
Flow Cytometry 2.5 μg/10^6 cells
Neutralization 0.08-0.4 μg/mL
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2RG Antibody Target Details IL2RG Application Details References for anti-IL2RG antibody (ABIN4899740) Images back to top
|Reconstitution||Sterile PBS to a final concentration of 0.5 mg/mL.|
|Buffer||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Storage||4 °C,-20 °C,-80 °C|
|Storage Comment||Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.|
|Expiry Date||12 months|
References for anti-IL2RG antibody (ABIN4899740)Product Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling Images back to top
|Product cited in:||
Jiang, Chen, An, Yang, Zhang, Cheng: "Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling." in: Scientific reports, Vol. 6, pp. 32320, 2016 Method employed by authors: Flow Cytometry (FACS), Flow Cytometry (FACS) (Sample species: Human).
Mujib, Jones, Lo, Aidarus, Clayton, Sakhdari, Benko, Kovacs, Ostrowski et al.: "Antigen-independent induction of Tim-3 expression on human T cells by the common ?-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 8, pp. 3745-56, 2012 Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).
Giron-Michel, Azzi, Khawam, Mortier, Caignard, Devocelle, Ferrini, Croce, François, Lecru, Charpentier, Chouaib, Azzarone, Eid: "Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway." in: PLoS ONE, Vol. 7, Issue 2, pp. e31624, 2012 Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).
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