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|Antigen||Janus Kinase 1 (JAK1) Antibodies|
|Epitope||AA 551-766 Alternatives|
|Reactivity||Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This JAK1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
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Product Details anti-JAK1 AntibodyTarget Details JAK1 Application Details Handling References for anti-JAK1 antibody (ABIN967842) Images
|Cross-Reactivity||Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken, Frog|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human JAK1 aa. 551-766|
Target Details JAK1Product Details anti-JAK1 Antibody Application Details Handling References for anti-JAK1 antibody (ABIN967842) Images back to top
|Alternative Name||JAK1 (JAK1 Antibody Abstract)|
|Background||The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.|
|Molecular Weight||130 kDa|
|Pathways||JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded protein response|
Application DetailsProduct Details anti-JAK1 Antibody Target Details JAK1 Handling References for anti-JAK1 antibody (ABIN967842) Images back to top
Related Products: ABIN968537, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-JAK1 Antibody Target Details JAK1 Application Details References for anti-JAK1 antibody (ABIN967842) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-JAK1 antibody (ABIN967842)Product Details anti-JAK1 Antibody Target Details JAK1 Application Details Handling Images back to top
|Product cited in:||
Kopantzev, Heller, Swaminathan, Rudikoff: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." in: Oncogene, Vol. 21, Issue 44, pp. 6791-800, 2002
Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, 2001
Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." in: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, 2001
Müller, Briscoe, Laxton, Guschin, Ziemiecki, Silvennoinen, Harpur, Barbieri, Witthuhn, Schindler: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." in: Nature, Vol. 366, Issue 6451, pp. 129-35, 1993
Nicholson, Oates, Harpur, Ziemiecki, Wilks, Layton: "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2985-8, 1994
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