|Antigen||Oncostatin M (OSM) Antibodies|
|Epitope||AA 25-206 Alternatives|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Oncostatin M antibody is un-conjugated Alternatives|
Cell Culture (CC), Western Blotting (WB)
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Product Details anti-Oncostatin M AntibodyTarget Details Oncostatin M Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Oncostatin M detection. Tested with WB, ELISA(Cap) in Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Oncostatin M detection. Tested with WB, ELISA(Cap) in Mouse,Rat.
Gene Name: oncostatin M
Protein Name: Oncostatin-M
|Purification||Immunogen affinity purified.|
|Immunogen||E. coli-derived mouse Oncostatin M recombinant protein (Position: N25-R206).|
Target Details Oncostatin MProduct Details anti-Oncostatin M Antibody Application Details Handling Images back to top
|Alternative Name||Osm (OSM Antibody Abstract)|
OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.
Synonyms: Oncostatin-M, OSM, Osm
|Pathways||JAK-STAT Signaling, Negative Regulation of Hormone Secretion|
Application DetailsProduct Details anti-Oncostatin M Antibody Target Details Oncostatin M Handling Images back to top
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Oncostatin M Antibody Target Details Oncostatin M Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C,-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.