anti-Human Prolactin Receptor antibody for ELISA (Detection)

Recommended Prolactin Receptor Antibody (supplied by: Log in to see )

Antigen
Prolactin Receptor (PRLR) Antibodies
  • PRL-R
  • prlr
  • PRLR
  • tprlr
  • DKFZp469D061
  • hPRLrI
  • AI987712
  • Pr-1
  • Pr-3
  • Prlr-rs1
  • RATPRLR
  • PRLRb
  • prolactin receptor
  • prlr-a
  • prlr-b
  • PRLR
  • prlr
  • Prlr
  • PR
Epitope
AA 1-234
15
7
6
6
6
5
5
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
206
67
36
17
17
16
15
15
13
2
2
2
2
1
Host
Rabbit
161
67
6
4
Clonality
Monoclonal
Conjugate
This Prolactin Receptor antibody is un-conjugated
7
7
7
7
6
6
6
6
6
6
6
6
6
5
4
4
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA, ELISA (Detection), Flow Cytometry (FACS), Immunofluorescence (IF), Immunofluorescence (fixed cells) (IF/ICC)
176
131
108
106
92
88
80
79
51
13
3
2
2
2
2
1
1
1
1
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Catalog No. ABIN1996249
$ 273.90
Plus shipping costs $45.00

General

Antigen Prolactin Receptor (PRLR) Antibodies
Epitope AA 1-234
(15), (7), (6), (6), (6), (5), (5), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(206), (67), (36), (17), (17), (16), (15), (15), (13), (2), (2), (2), (2), (1)
Host Rabbit
(161), (67), (6), (4)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Prolactin Receptor antibody is un-conjugated
(7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, ELISA (Detection), Flow Cytometry (FACS), Immunofluorescence (IF), Immunofluorescence (fixed cells) (IF/ICC)
(176), (131), (108), (106), (92), (88), (80), (79), (51), (13), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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Product Details anti-Prolactin Receptor Antibody

Target Details Prolactin Receptor Application Details Handling Images
Specificity Human PRLR / Prolactin Receptor
Characteristics This antibody was obtained from a rabbit immunized with purified, recombinant Human PRLR (rh PRLR, ABIN2002498 NP_000940.1, Met 1-Asp 234,.
Sterility 0.2 μm filtered
Immunogen Recombinant Human PRLR protein (ABIN2002498)
Clone 204
Isotype IgG

Target Details Prolactin Receptor

Product Details anti-Prolactin Receptor Antibody Application Details Handling Images back to top
Antigen
Alternative Name PRLR (PRLR Antibody Abstract)
Background Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the typeI cytokine receptor superfamily, and contains two fibronectin type-III domains. PRLR is widely expressed in breast, placenta, kidney, liver and pancreas, and mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules invloved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. It has been shown that specific binding to PRLR can stimulate the breast cancer cells to grow and certain antagonists which bind but do not dimerize PRLR can inhibit the growth of breast cancer cells. Several isoforms have been described, and the soluble form are unable to transduce prolactin signaling.
NCBI Accession NP_000940.1
Pathways JAK-STAT Signaling, Response to Growth Hormone Stimulus

Application Details

Product Details anti-Prolactin Receptor Antibody Target Details Prolactin Receptor Handling Images back to top
Application Notes ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human PRLR. The detection limit for Human PRLR is approximately 0.00245 ng/well.
ELISA(Det): 0.1-1 μg/mL
ICC/IF: 10-25 μg/mL
FCM: 0.5-2 μg/Test
Restrictions For Research Use only

Handling

Product Details anti-Prolactin Receptor Antibody Target Details Prolactin Receptor Application Details Images back to top
Format Liquid
Buffer 0.2 μm filtered solution in PBS
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months

Images

Product Details anti-Prolactin Receptor Antibody Target Details Prolactin Receptor Application Details Handling back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Prolactin Receptor (PRLR) (AA 1-234) antibody (ABIN1996249) anti-Prolactin Receptor (PRLR) (AA 1-234) antibody
Immunofluorescence (IF) image for anti-Prolactin Receptor (PRLR) (AA 1-234) antibody (ABIN1996249) anti-Prolactin Receptor (PRLR) (AA 1-234) antibody (Image 2)