We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Serotonin Receptor 2B (HTR2B) Antibodies|
|Epitope||AA 1-58 Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This Serotonin Receptor 2B antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-Serotonin Receptor 2B AntibodyTarget Details Serotonin Receptor 2B Application Details Handling References for anti-Serotonin Receptor 2B antibody (ABIN967504) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human 5HT[2B]R (aa. 1-58) fusion protein|
Target Details Serotonin Receptor 2BProduct Details anti-Serotonin Receptor 2B Antibody Application Details Handling References for anti-Serotonin Receptor 2B antibody (ABIN967504) Images back to top
|Alternative Name||Serotonin Receptor 5-HT 2BR (HTR2B Antibody Abstract)|
|Background||Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor, plays an important role in regulating diverse biological processes in the central and peripheral nervous systems, the cardiovascular system and the gastrointestinal systems. The different functions of serotonin are thought to be mediated through specific receptors. Physiological, biochemical, and pharmacological studies have defined at least fourteen serotonin receptors. The fourteen receptors are grouped in seven subtypes according to operational, structural, and transductional properties. The 5-HT2 receptors (5 -HT[2A]R, 5-HT[2B]R, an d 5-HT[2C]R) may be considered as prototypes for the study of serotonin receptors . Their functions are mediated by the second messenger inositol polyphosphate in a G-protein coupled pathway. They are expressed in diverse tissues including brain, vascular smooth muscles and platelets. The 5-HT[2A]R-mRNAs have been found in only a few areas of the brain, including the frontal cortex, piriform cortex, ventro-caudal part of CA3, motor cranial nerve nuclei in the brainstem, and the ventral horn of the spinal cord. The 5-HT[2C]R mRNA has been found at high levels in many parts of the brain including retrosplenial piriform and entorhinal cortex, anterior olfactory nucleus, substantia nigra pars compacta, several brainstem nuclei and the whole grey matter of the spinal cord. The 5-HT[2B]R was cloned in stomach fundus, where it is abundantly expressed.|
|Molecular Weight||45-55 kDa|
|Pathways||JAK-STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process|
Application DetailsProduct Details anti-Serotonin Receptor 2B Antibody Target Details Serotonin Receptor 2B Handling References for anti-Serotonin Receptor 2B antibody (ABIN967504) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-Serotonin Receptor 2B Antibody Target Details Serotonin Receptor 2B Application Details References for anti-Serotonin Receptor 2B antibody (ABIN967504) Images back to top
|Buffer||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at 4°C.|
References for anti-Serotonin Receptor 2B antibody (ABIN967504)Product Details anti-Serotonin Receptor 2B Antibody Target Details Serotonin Receptor 2B Application Details Handling Images back to top
|Product cited in:||
Duxon, Flanigan, Reavley, Baxter, Blackburn, Fone: "Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system." in: Neuroscience, Vol. 76, Issue 2, pp. 323-9, 1997
Saudou, Hen: "5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates." in: Neurochemistry international, Vol. 25, Issue 6, pp. 503-32, 1995
Pompeiano, Palacios, Mengod: "Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors." in: Brain research. Molecular brain research, Vol. 23, Issue 1-2, pp. 163-78, 1994
Humphrey, Hartig, Hoyer: "A proposed new nomenclature for 5-HT receptors." in: Trends in pharmacological sciences, Vol. 14, Issue 6, pp. 233-6, 1993
Foguet, Hoyer, Pardo, Parekh, Kluxen, Kalkman, Stühmer, Lübbert: "Cloning and functional characterization of the rat stomach fundus serotonin receptor." in: The EMBO journal, Vol. 11, Issue 9, pp. 3481-7, 1992
ImagesProduct Details anti-Serotonin Receptor 2B Antibody Target Details Serotonin Receptor 2B Application Details Handling References for anti-Serotonin Receptor 2B antibody (ABIN967504) back to top