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anti-Rat (Rattus) CEP250 Antibodies:
anti-Mouse (Murine) CEP250 Antibodies:
anti-Human CEP250 Antibodies:
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Caprine-like Generalized Hypoplasia Syndrome is caused by a truncating mutation in the CEP250 gene. Loss of C-Nap1-mediated centriole cohesion leads to an altered cell migration phenotype.
CEP2 attenuates myoblast differentiation but does not affect proliferation.
C-NAP1-null cells were viable and had an increased frequency of premature centriole separation, accompanied by reduced density of the centriolar satellites, with reexpression of C-NAP1 rescuing both phenotypes. Centrosome amplification induced by DNA damage or by PLK4 (show PLK4 Antibodies) or CDK2 (show CDK2 Antibodies) overexpression was markedly reduced in the absence of C-NAP1.
ASPP1 (show PPP1R13B Antibodies)/2 interacted with centrosome linker protein (show LAT Antibodies) C-Nap1. Co-depletion of ASPP1 (show PPP1R13B Antibodies) and ASPP2 (show TP53BP2 Antibodies) inhibited re-association of C-Nap1 with centrosome at the end of mitosis.
A homozygous nonsense CEP250 mutation, in combination with a heterozygous C2orf71 (show C2orf71 Antibodies) nonsense mutation, causes an atypical form of Usher syndrome, characterised by early-onset sensorineural hearing loss and a relatively mild retinitis pigmentosa.
Centlein complexes with C-Nap1 and Cep68 at the proximal ends of centrioles during interphase.
C-NAP1 and rootletin (show CROCC Antibodies) restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.
Data show that the dissociation of C-Nap1 from mitotic centrosomes is regulated by localized phosphorylation rather than generalized proteolysis.
CEP135 (show CEP135 Antibodies) acts as a platform protein for C-NAP1 at the centriole.
This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome.
centrosomal protein 250kDa
, centrosome-associated protein CEP250
, centrosomal protein 250kDa, isoform 1
, centrosomal protein 2
, centrosome-associated protein CEP250-like
, 250 kDa centrosomal protein
, centrosomal Nek2-associated protein 1
, intranuclear matrix protein
, centrosomal protein, 250-KD
, centrosome associated protein