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kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E (show CENPE Proteins) motor.
These data strongly indicated that KNTC2 is a promising target for the treatment of HCC (show FAM126A Proteins) and that phosphorylated HH3 (show PROKR2 Proteins) at serine 10 is one of the target engagement markers for KNTC2.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
Hec1-dependent cyclin B2 (show CCNB2 Proteins) stabilization during early metaphase is important for early-stage spindle assembly.
Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.
overexpression of Hec1 results in mitotic checkpoint (show BUB3 Proteins) hyperactivation that leads to aneuploidy sufficient to generate tumors
Study shows that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component, also show that this phosphorylation occurs specifically during mitosis and is required for the kinetochore localization of the Ska complex.
This study suggests that Ndc80 may play an important role in the process of hepatitis B virus-related hepatocellular carcinoma, and that it may be a potential biological treatment target in the future.
Whereas CENP-C recruits a single MIS12 (show MIS12 Proteins):NDC80 complex, the authors show here that CENP-T (show CENPT Proteins) binds one MIS12 (show MIS12 Proteins):NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1 (show CDK1 Proteins):Cyclin B complex at three distinct CENP-T (show CENPT Proteins) sites.
Ska is recruited to kinetochores by clusters of Ndc80 proteins.
Expression of NDC80 in colon cancer cells and tissues was higher than that in controls. NDC80 promotes the proliferation and metastasis of colon cancer cells.
Ndc80 complex bound to microtubules binds every tubulin (show TUBB Proteins) monomer along the microtubule protofilament.
we conclude that Hec1 is consistently overexpressed in human PCa (show FLVCR1 Proteins) and Hec1 is closely linked with human PCa (show FLVCR1 Proteins) progression through the meditator LncRNA BX647187
Independent molecular binding events to microtubules (MTs (show TIMM8A Proteins)) by individual NDC80 complexes, rather than their structured oligomers, regulate the dynamics and stability of kinetochore-MT attachments in dividing cells.
The Ndc80 complex binds straight microtubules by recognizing the dimeric interface of tubulin (show TUBB Proteins).
Overproduction of Ndc80 in cancer cells may unfavourably absorb protein interactors through the internal loop domain and lead to a change in the equilibrium of microtubule-associated proteins. [Review]
mature attachment via the Ndc80 complex is essential for metaphase alignment and anaphase A
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
kinetochore associated 2
, NDC80 homolog, kinetochore complex component (S. cerevisiae)
, NDC80 homolog, kinetochore complex component
, kinetochore protein NDC80 homolog
, kinetochore protein Ndc80
, Kinetochore protein NDC80 homolog
, highly expressed in cancer, rich in leucine heptad repeats
, kinetochore protein Hec1
, kinetochore-associated protein 2
, HEC (highly expressed in cancer)
, NDC80 kinetochore complex component homolog
, highly expressed in cancer protein
, retinoblastoma-associated protein HEC
, kinetochore spindle checkpoint protein Ndc80