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|Antigen||Regulator of G-Protein Signaling 1 (RGS1) Antibodies|
|Conjugate||This RGS1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-RGS1 AntibodyTarget Details RGS1 Application Details Handling References for anti-RGS1 antibody (ABIN453811) Images
|Specificity||This antibody reacts to RGS1.|
|Purification||Affinity chromatography on Protein A|
|Immunogen||KLH conjugated synthetic peptide selected from the N-term region of human RGS1|
Target Details RGS1Product Details anti-RGS1 Antibody Application Details Handling References for anti-RGS1 antibody (ABIN453811) Images back to top
|Alternative Name||RGS1 (RGS1 Antibody Abstract)|
|Background||RGS1 is a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.Synonyms: 1R20, B-cell activation protein BL34, BL34, Early response protein 1R20, IER1, Regulator of G-protein signaling 1|
|Research Area||Signaling, Immunology|
|Pathways||MAPK Signaling, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events|
Application DetailsProduct Details anti-RGS1 Antibody Target Details RGS1 Handling References for anti-RGS1 antibody (ABIN453811) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-RGS1 Antibody Target Details RGS1 Application Details References for anti-RGS1 antibody (ABIN453811) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-RGS1 antibody (ABIN453811)Product Details anti-RGS1 Antibody Target Details RGS1 Application Details Handling Images back to top
Bowman, Campbell, Druey, Scheschonka, Kehrl, Butcher: "Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members." in: The Journal of biological chemistry, Vol. 273, Issue 43, pp. 28040-8, 1998
ImagesProduct Details anti-RGS1 Antibody Target Details RGS1 Application Details Handling References for anti-RGS1 antibody (ABIN453811) back to top