anti-Human SIRT1 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended SIRT1 Antibody (supplied by: Log in to see )

Antigen
Sirtuin 1 (SIRT1) Antibodies
  • sirtuin 1
  • AA673258
  • SIR2L1
  • Sir2
  • Sir2a
  • Sir2alpha
  • sir2l1
  • sirtuin
  • SIR2
  • sirtuin 1
  • sirtuin 1 L homeolog
  • SIRT1
  • SRT1
  • Sirt1
  • sirt1.L
Epitope
AA 192-242
26
26
17
15
14
12
11
11
10
7
6
6
5
5
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
314
150
71
21
13
11
7
7
7
6
5
4
4
2
2
2
2
1
Host
Rabbit
217
84
30
6
3
Clonality
Polyclonal
Conjugate
This SIRT1 antibody is un-conjugated
18
15
9
7
7
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
266
141
107
69
61
46
43
42
39
14
6
4
4
2
2
2
2
2
1
1
Options
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Catalog No. ABIN729853
$ 318.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN745658 IF (p) IHC (p) WB Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 2
1 ABIN746003 IF (p) IHC (p) WB Rabbit IgG AA 1-50, pSer27 Log in to see Polyclonal 0
1 ABIN679028 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN915277 IF (p) Alexa Fluor 488 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN915276 IF (p) Alexa Fluor 555 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN915278 IF (p) Alexa Fluor 647 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN915279 IF (p) Alexa Fluor 350 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN729858 IF (p) Cy5.5 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN729859 IF (p) Cy7 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN729860 IF (p) FITC Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN729857 IF (p) Cy5 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN729856 IF (p) Cy3 Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN745661 IF (p) Cy3 Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN745663 IF (p) Cy5.5 Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN745662 IF (p) Cy5 Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN745664 IF (p) Cy7 Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN745665 IF (p) FITC Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN876312 IF (p) Alexa Fluor 647 Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN876311 IF (p) Alexa Fluor 555 Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN876309 IF (p) Alexa Fluor 350 Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0

General

Antigen Sirtuin 1 (SIRT1) Antibodies
Epitope AA 192-242
(26), (26), (17), (15), (14), (12), (11), (11), (10), (7), (6), (6), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(314), (150), (71), (21), (13), (11), (7), (7), (7), (6), (5), (4), (4), (2), (2), (2), (2), (1)
Host Rabbit
(217), (84), (30), (6), (3)
Clonality
Polyclonal
Conjugate This SIRT1 antibody is un-conjugated
(18), (15), (9), (7), (7), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(266), (141), (107), (69), (61), (46), (43), (42), (39), (14), (6), (4), (4), (2), (2), (2), (2), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-SIRT1 Antibody

Target Details SIRT1 Application Details Handling References for anti-SIRT1 antibody (ABIN729853) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human SIRT1
Isotype IgG
Plasmids, Primers & others

Target Details SIRT1

Product Details anti-SIRT1 Antibody Application Details Handling References for anti-SIRT1 antibody (ABIN729853) Images back to top
Antigen
Alternative Name SIRT1 (SIRT1 Antibody Abstract)
Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Subcellular location: Cytoplasm, Nucleus

Synonyms: SIR2L1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SIRT1

Gene ID 23411
UniProt Q96EB6
Pathways MAPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling

Application Details

Product Details anti-SIRT1 Antibody Target Details SIRT1 Handling References for anti-SIRT1 antibody (ABIN729853) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details References for anti-SIRT1 antibody (ABIN729853) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-SIRT1 antibody (ABIN729853)

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling Images back to top
Product cited in:

Yan, Jin, Cao, Wang, Lu, Yang, Wu, Cai: "Effects of Aluminium on Long-Term Memory in Rats and on SIRT1 Mediating the Transcription of CREB-Dependent Gene in Hippocampus." in: Basic & clinical pharmacology & toxicology, Vol. 121, Issue 4, pp. 342-352, 2017 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: brain

Hu, Fan, Lv, Zhou, Yang, Zheng, Cao: "5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis." in: Journal of dermatological science, Vol. 79, Issue 2, pp. 155-62, 2015 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: tumor

Mohan, Kumar, Lackner, Alvarez: "Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 1, pp. 291-306, 2014 Further details: Sample: Colon

Images

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling References for anti-SIRT1 antibody (ABIN729853) back to top
Supplier Images
SDS-PAGE (SDS) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Lane 1: mouse liver lysates Lane 2: mouse brain lysates probed with Anti SIRT1 Polycl...
Immunohistochemistry (IHC) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Formalin-fixed and paraffin embedded human endometrial carcinoma labeled with Anti-SI...
Immunohistochemistry (IHC) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-SIRT1 ...
Western Blotting (WB) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Protein: mouse heart lysate;
Primary: rabbit Anti-SIRT1 at 1: 5000;
Predic...
Western Blotting (WB) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Hela cell lysates probed with Anti-SIRT1 Polyclonal Antibody, Unconjugated at 1:3000...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-SIRT1 ...
 image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) MCF-7 cells probed with SIRT1 Polyclonal Antibody, unconjugated at 1:100 dilution fo...