anti-Human SIRT1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended SIRT1 Antibody (supplied by: Log in to see )

Antigen
Sirtuin 1 (SIRT1) Antibodies
  • sirtuin 1
  • AA673258
  • SIR2L1
  • Sir2
  • Sir2a
  • Sir2alpha
  • sir2l1
  • sirtuin
  • SIR2
  • sirtuin 1
  • sirtuin 1 L homeolog
  • SIRT1
  • SRT1
  • Sirt1
  • sirt1.L
Epitope
AA 192-242
30
24
21
17
16
15
14
12
10
6
6
5
4
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
308
139
68
21
14
11
7
7
7
6
5
4
4
2
2
2
2
1
Host
Rabbit
206
88
28
6
3
Clonality
Polyclonal
Conjugate
This SIRT1 antibody is un-conjugated
17
14
10
7
7
6
6
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
262
142
89
66
59
51
42
39
33
7
6
4
4
2
2
2
2
2
1
1
Options
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Catalog No. ABIN729853
$ 318.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.839581 ABIN4353901 ELISA FACS ICC IF IHC IHC (p) WB Mouse IgG1 Log in to see 1F3 1
12.839581 ABIN4353903 ICC IF IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 3
12.839581 ABIN745658 IF (p) IHC (p) WB Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 2
12.839581 ABIN239843 IHC (p) IP WB Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN1500927 ELISA FACS ICC IF IHC (p) WB Mouse IgG1 Log in to see 1F3 0
1 ABIN565071 IF IHC (p) ELISA WB Mouse IgG1 kappa AA 456-555, partial Log in to see 7B7 3
1 ABIN372326 IHC (p) IP WB Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN1493902 IHC (p) ELISA WB Goat AA 577-590 Log in to see Polyclonal 0
1 ABIN214144 IHC (p) WB Rabbit IgG AA 207-256 Log in to see Polyclonal 0
1 ABIN1999249 ELISA IF IF/ICC IHC (p) Mouse IgG1 AA 193-747 Log in to see 3H10A10 0
1 ABIN614713 EIA IF IHC (p) WB Mouse IgG1 AA 456-555 Log in to see 7B7 0
1 ABIN746003 IF (p) IHC (p) WB Rabbit IgG AA 1-50, pSer27 Log in to see Polyclonal 0
1 ABIN1109014 EIA FACS IF IHC (p) WB Mouse IgG1 Log in to see 1F3 2
1 ABIN3201829 ICC IHC (fro) IHC (p) ELISA WB Mouse IgG AA 244-498 Log in to see 0
1 ABIN4353899 ICC IF IHC IHC (p) SimWes WB Rabbit AA 400-550, Internal Region Log in to see Polyclonal 0
1 ABIN574445 IF IHC (p) ELISA WB Mouse IgG1, kappa AA 456-555 Log in to see 7B7 0
1 ABIN679028 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN729862 IHC (p) WB HRP Rabbit IgG AA 192-242 Log in to see Polyclonal 0
1 ABIN745667 IHC (p) WB HRP Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal 0
1 ABIN1723581 IF IHC (p) ELISA WB Mouse IgG1 kappa AA 456-555 Log in to see 7B7 0

General

Antigen Sirtuin 1 (SIRT1) Antibodies
Epitope AA 192-242
(30), (24), (21), (17), (16), (15), (14), (12), (10), (6), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(308), (139), (68), (21), (14), (11), (7), (7), (7), (6), (5), (4), (4), (2), (2), (2), (2), (1)
Host Rabbit
(206), (88), (28), (6), (3)
Clonality
Polyclonal
Conjugate This SIRT1 antibody is un-conjugated
(17), (14), (10), (7), (7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(262), (142), (89), (66), (59), (51), (42), (39), (33), (7), (6), (4), (4), (2), (2), (2), (2), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-SIRT1 Antibody

Target Details SIRT1 Application Details Handling References for anti-SIRT1 antibody (ABIN729853) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human SIRT1
Isotype IgG

Target Details SIRT1

Product Details anti-SIRT1 Antibody Application Details Handling References for anti-SIRT1 antibody (ABIN729853) Images back to top
Antigen
Alternative Name SIRT1 (SIRT1 Antibody Abstract)
Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Subcellular location: Cytoplasm, Nucleus

Synonyms: SIR2L1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SIRT1

Gene ID 23411
UniProt Q96EB6
Pathways MAPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling

Application Details

Product Details anti-SIRT1 Antibody Target Details SIRT1 Handling References for anti-SIRT1 antibody (ABIN729853) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details References for anti-SIRT1 antibody (ABIN729853) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-SIRT1 antibody (ABIN729853)

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling Images back to top
Product cited in:

Yan, Jin, Cao, Wang, Lu, Yang, Wu, Cai: "Effects of Aluminium on Long-Term Memory in Rats and on SIRT1 Mediating the Transcription of CREB-Dependent Gene in Hippocampus." in: Basic & clinical pharmacology & toxicology, Vol. 121, Issue 4, pp. 342-352, 2017 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: brain

Hu, Fan, Lv, Zhou, Yang, Zheng, Cao: "5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis." in: Journal of dermatological science, Vol. 79, Issue 2, pp. 155-62, 2015 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: tumor

Mohan, Kumar, Lackner, Alvarez: "Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 1, pp. 291-306, 2014 Further details: Sample: Colon

Images

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling References for anti-SIRT1 antibody (ABIN729853) back to top
Supplier Images
SDS-PAGE (SDS) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Lane 1: mouse liver lysates Lane 2: mouse brain lysates probed with Anti SIRT1 Polycl...
Immunohistochemistry (IHC) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Formalin-fixed and paraffin embedded human endometrial carcinoma labeled with Anti-SI...
Immunohistochemistry (IHC) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-SIRT1 ...
Western Blotting (WB) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Protein: mouse heart lysate;
Primary: rabbit Anti-SIRT1 at 1: 5000;
Predic...
Western Blotting (WB) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Hela cell lysates probed with Anti-SIRT1 Polyclonal Antibody, Unconjugated at 1:3000...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-SIRT1 ...
 image for anti-Sirtuin 1 (SIRT1) (AA 192-242) antibody (ABIN729853) MCF-7 cells probed with SIRT1 Polyclonal Antibody, unconjugated at 1:100 dilution fo...