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Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
miR (show MLXIP Proteins)-323-3p appears to be a crucial diabetes factor that mediates its functions by inhibiting the AdipoR1 (show ADIPOR1 Proteins)/AMPK (show PRKAA1 Proteins)/SIRT-1 signaling pathway.
During catecholamine-stimulated lipolysis, Perilipin 5 (show PLIN5 Proteins) is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus. Perilipin 5 (show PLIN5 Proteins) promotes PGC-1alpha co-activator function by disinhibiting SIRT1 deacetylase activity.
findings demonstrate a new mechanism for the activation of SIRT1 under stress conditions and suggest a novel potential therapeutic target for preventing age-related diseases and extending healthspan
SIRT1 was inhibited or knocked out in macrophages, the protection effect disappeared by treatment of inhibitor of mir (show MLXIP Proteins)-138, and the NFkappaB pathway was activated and the AKT (show AKT1 Proteins) pathway was inhibited
the results of the present study suggest that moderate overexpression of SIRT1 (~3fold of normal level) may directly or indirectly inhibit apoptosis of OBs via the FOXO1 and betacatenin signaling pathway.
Overexpression of miR (show MLXIP Proteins)-22 can attenuate oxidative stress injury in diabetic cardiomyopathy by upregulation of Sirt 1.
caloric restriction rescues SIRT1 levels in transgenic Machado-Joseph disease (MJD (show ATXN3 Proteins)) mice, whereas silencing SIRT1 is sufficient to prevent the beneficial effects on MJD (show ATXN3 Proteins) pathology.
the findings identify a gut (show GUSB Proteins)-vascular axis in which Gut (show GUSB Proteins) microbiota remotely upregulate miR (show MLXIP Proteins)-204 expression in the vessel wall. Among the genes targeted by miR (show MLXIP Proteins)-204 in the vascular wall is Sirt1, downregulation of which promotes endothelial dysfunction.
melatonin oral supplementation may represent a new protective approach to block hypercholesterolemic liver alterations involving also a SIRT1-dependent mechanism.
Melatonin promoted MnSOD (show SOD2 Proteins) and SIRT1 expression, which successfully ameliorated busulfan-induced SSC (show CYP11A1 Proteins) apoptosis caused by high concentrations of ROS (show ROS1 Proteins) and p53 (show TP53 Proteins)
High Sirt1 Expression is associated with Gastric cancer.
Sirt1 protects against oxidative stress-induced (show SQSTM1 Proteins) apoptosis in fibroblasts from psoriatic patients.
Investigated the effect of statins on the expression of sirtuin 1 (SIRT1) and endothelial nitric oxide synthase 3 (eNOS) proteins in young premature myocardial infarction (PMI (show MPI Proteins)) patients. Found patients with PMI (show MPI Proteins) who were taking statins had a markedly higher level of SIRT1 compared with the controls. The level of eNOS (show NOS3 Proteins) protein was considerably lower in PMI (show MPI Proteins) patients compared with the control group.
Clinical data are the first to identify SIRT1 as an important regulator of hepatocellular function in human liver transplants under ischemia/reperfusion stress.
suggests SIRT1 may serve as a predictor of poor prognosis in esophageal squamous cell carcinoma, and its mediated tumor-promoting role might be associated with the overexpression of EGFR (show EGFR Proteins) protein in esophageal squamous cell carcinoma
This study represents the important role of Sirt1 and senescence in the regulation of beige adipocyte differentiation during aging.
Baicalin activated the SIRT1/AMPK (show PRKAA1 Proteins) and mechanistic target of rapamycin (mTOR (show FRAP1 Proteins)), and SIRT1/AMPK (show PRKAA1 Proteins) and matrix metalloproteinase (MMP) signaling in A549 and H1299 cells in a dose-dependent manner. siRNA silencing of SIRT1 and AMPK (show PRKAA1 Proteins) reduced the effects of baicalin on cell proliferation and migration.
We provide a comprehensive overview of recent developments on the molecular signaling pathways controlled by SIRT1 and SIRT6 (show SIRT6 Proteins), two post-translational modifiers proven to be valuable tools to dampen inflammation and oxidative stress at the cardiovascular levell
SIRT1 was identified as a direct target of miR (show MLXIP Proteins)-212 and its expression was inversely correlated with miR (show MLXIP Proteins)-212 expression in thyroid cancer tissues. Overexpression of SIRT1 could effectively rescue miR (show MLXIP Proteins)-212 mimic-induced suppression of cell proliferation, migration and invasion in TPC-1 (show TPCN1 Proteins) thyroid cancer cell line.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.
CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.
This is the first study demonstrating a role for AMPK (show PRKAA1 Proteins)-SIRT1-FOXO1 (show FOXO1 Proteins) signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1