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Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 (show CRMP1 Proteins) directly.
Compared with control-diet mice, mice given an high-fat diet (HFD) for 4weeks displayed anxiolytic-like behaviors. At the same time, we observed decreased SIRT1 expression in the medial prefrontal cortex and the amygdala of HFD-fed mice. Resveratrol, an activator of SIRT1, reversed the anxiolytic-like behaviors in HFD-fed mice.
These findings support the unifying concept that nuclear NAD(+) sensor SIRT1 broadly coordinates innate and adaptive immune reprogramming during sepsis
Low SIRT1 expression is associated with Parkinson's disease.
SUV39H (show SUV39H1 Proteins) augments intracellular reactive oxygen species levels in a SIRT1-dependent manner.
our data strongly indicate that melatonin delays postovulatory mouse oocyte aging via a SIRT1-MnSOD (show SOD2 Proteins)-dependent pathway
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 (show CD36 Proteins) and the NF-kappaB (show NFKB1 Proteins) pathway in mouse Kupffer cells.
Low expression of SIRT1 is associated with Human immunodeficiency virus-associated nephropathy.
SIRT1 levels were down-regulated in the livers in models of liver fibrosis and in activated hepatic stellate cells (HSCs) as opposed to quiescent HSCs. SIRT1 activation halted, whereas SIRT1 inhibition promoted, HSC (show FUT1 Proteins) transdifferentiation into myofibroblasts.
Sirt1 preserves Cav1 (show CAV1 Proteins)-dependent endothelial function by mitigating miR (show MLXIP Proteins)-204-mediated vascular endoplasmic reticulum stress.
Adipose tissue sirtuin 1 was related to insulin (show INS Proteins) sensitivity. The relationship was still present after controlling for BMI, however, it disappeared after controlling for adipose tissue SLC2A4 (show SLC2A4 Proteins). Muscle sirtuin 1 was not related to insulin (show INS Proteins) sensitivity.
data suggest that SIRT1 is an oncogenic factor in breast cancer cells and can be involved in the progression of breast cancer by inhibiting p53 (show TP53 Proteins) and activating POLD1 (show POLD1 Proteins)
SIRT1 expression is significantly upregulated in paclitaxel-resistant cervical cancer tissues and cell lines compared to normal tissues or PTX-sensitive CC tissues and cell lines. Knockdown of SIRT1 inhibited the cell proliferation, promoted cell cycle arrest and apoptosis of PTX-sensitive CC cells, and decreased the expression of MDR proteins.
In our retrospective study, high SIRT1 expression significantly correlated with vascular invasion and a worse prognosis in colorectal cancer
SIRT1 polymorphisms and their expression were associated with the presence of alcoholic fatty liver disease (AFLD), and there was a close relationship among four SNPs and body mass index in AFLD patients, but no SNP was related to its expression.
The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells.
Results indicate that SIRT1 may promote the metastasis of chondrosarcoma by inducing epithelial-mesenchymal transition and can be a potential molecular target for chondrosarcoma therapy.
Regulation of transmembrane-4-L-six-family-1 (TM4SF1 (show TM4SF1 Proteins)) on bladder cancer cell could be induced by peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Proteins))-sirtuin 1 (SIRT1) feedback loop.
Results present evidence that SIRT1 plays an essential role in regulating the transcription of CLDN5 (show CLDN5 Proteins) likely by modifying and modulating the activity of KLF4 (show KLF4 Proteins) in ovarian cancer cells.
Our results showed that administration of Hcy reduced the SIRT1/AMPK/PGC-1alpha signaling in chondrocytes, leading to mitochondrial dysfunction as a result of increased oxidative stress and apoptosis
The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1/Nrf2 (show NFE2L2 Proteins) and p38 MAPK (show MAPK14 Proteins) pathways.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.
CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
This is the first study demonstrating a role for AMPK (show PRKAA1 Proteins)-SIRT1-FOXO1 (show FOXO1 Proteins) signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1