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Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
Mesenchymal stem cells-Sirt1 can effectively inhibit prostate cancer growth recruiting NK cells and macrophages in a tumor inflammatory microenvironment.
Study found that primary mouse embryonic fibroblast (MEF) cells undergo progressive decline of NAMPT (show NAMPT Proteins) and NAD(+) contents during serial passaging before becoming senescent; further found that constitutive Nampt (show NAMPT Proteins) over-expression increases SIRT1 activity, increases the expression of antioxidant genes, superoxide dismutase 2 (show SOD2 Proteins) and catalase (show CAT Proteins) and promotes resistance against oxidative stress.
MiR (show MLXIP Proteins)-211 could promote apoptosis and inhibit proliferation of lens epithelial cells in diabetic cataract mice by targetting SIRT1.
The metabolic effects were associated with activation of the SIRT1-LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) signalling pathway in adipose tissue and liver.
After 6 weeks of environmental tobacco smoke exposure, the Sirt-1 protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R (show IGF2R Proteins) cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced.
findings unveil an important link between environmental cues, SIRT1 phosphorylation, and energy homeostasis and demonstrate that the phosphorylation of T522 is a critical element in tissue-specific regulation of SIRT1 activity in vivo
SIRT1 physically interacts with and deacetylates eIF2alpha (show EIF2A Proteins) and is a novel regulatory mechanism for protecting cardiac cells from endoplasmic reticulum stress.
Findings indicate that protein inhibitor of activated STAT 4 (PIAS4 (show PIAS4 Proteins)) mediated SIRT1 repression in response to nutrient surplus contributes to the pathogenesis of Nonalcoholic Steatohepatitis (NASH (show SAMSN1 Proteins)).
Berberine could attenuate oxidative stress of diabetic mice at least partly through miR (show MLXIP Proteins)-106b/SIRT1 pathway and affecting the function of islets, which might be beneficial in reducing the cardiovascular risk factors in diabetes.
ATGL (show PNPLA2 Proteins) acts as an important upstream signaling node that, via SIRT1, increases autophagy/lipophagy as a means to promote hepatic lipid droplet catabolism.
Taken together, our results indicated that miR (show MLXIP Proteins)-449 overexpression inhibited osteogenic differentiation of HG-FFA-treated hBMSCs through the Sirt1/Fra-1 (show FOSL1 Proteins) signal pathway.
The influence of diets on metabolic processes associated with sirtuin1.
these results demonstrate that the reversible acetylation of FOXM1 (show FOXM1 Proteins) by p300/CBP (show CREBBP Proteins) and SIRT1 modulates its transactivation function
miR (show MLXIP Proteins)-212 facilitates macrophage foam cell formation and suppresses ABCA1 (show ABCA1 Proteins)-dependent cholesterol efflux through downregulation of SIRT1.
By downregulating acetylated LKB1 (show STK11 Proteins) protein via HERC2, SIRT1 fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis
Findings indicated that the miR (show MLXIP Proteins)-29b/SIRT1 axis has a protective effect against H2O2-induced damage of cell viability and oxidative stress and may provide novel options for miR (show MLXIP Proteins)-29b-based therapeutic approaches for EOC treatment.
High SIRT1 expression is associated with liver cancer.
Our findings clearly evidenced a novel and negative role of miR (show MLXIP Proteins)-199b in the regulation of SIRT1 in colorectal cancer cells
We found a negative correlation between mRNA levels of SIRT1 in VAT of obese individuals and SIRT7 (show SIRT7 Proteins) in VAT of the normal-weight subjects and expression of the relevant miRNAs.
SIRT1 activation induces STAT3 (show STAT3 Proteins) deacetylation, reducing its ability to translocate into the nucleus, bind to Rorc (show RORC Proteins) promoter, and induce its transcription.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.
CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1