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Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1 (show PABPC1 Proteins).
L-Carnitine alleviated epithelial mesenchymal transformation-associated renal fibrosis caused by perfluorooctanesulfonate through a Sirt1- and PPARgamma (show PPARG Proteins)-dependent mechanism.
CACUL1 reciprocally regulates SIRT1 and LSD1 (show KDM1A Proteins) to repress PPARgamma (show PPARG Proteins) and inhibit adipogenesis.
The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 activation, which in turn increases IRS1 (show IRS1 Proteins) phosphorylation and GLUT4 (show SLC2A4 Proteins) translocation in myotubes.
PU.1 suppresses Sirt1 translation via transcriptional promotion of miR (show MLXIP Proteins)-34a/-29c.
Impairment of energy sensors, SIRT1 and AMPK (show PRKAA1 Proteins), in lipid induced inflamed adipocyte is regulated by Fetuin A (show AHSG Proteins).
this study revealed a new mechanism wherein EPO (show EPO Proteins) alleviates hepatic steatosis by activating autophagy via SIRT1-dependent deacetylation of LC3 (show MAP1LC3A Proteins).
Retinoic acid (RA) increases the expression of hepatic Sirt1 and inhibits the expression of sterol regulatory element binding protein (show CNBP Proteins) 1c (Srebp-1c (show SREBF1 Proteins)) in WT mice in vivo and in vitro. RA-mediated molecular effects are abolished in the liver and primary hepatocytes from Sirtuin 1 (Sirt1) deficient (LKO) mice.
thymoquinone inhibits cellular ROS generation in LPS-activated BV2 microglia. It is also suggested that activation of both AMPK and NAD(+)/SIRT1 may contribute to the anti-inflammatory, but not antioxidant activity of the compound in BV2 microglia.
SIRT1 signaling is important for alleviation of sepsis-induced myocardial injury and for enhancement of the protective effect of a liver X receptor agonist.
decreased SIRT1 expression and its SUMOylation by SUMO1 (show SUMO1 Proteins) and SUMO2 (show SUMO2 Proteins)/3 may be associated with the development of bronchopulmonary dysplasia.
High SIRT1 expression is associated with hepatocellular carcinoma.
No significant association has been discovered between SIRT1 polymorphisms and diabetic foot severity or characteristics
A significant correlation between the physical activity level and peripheral blood mononuclear cell SIRT1 and FOXO1 (show FOXO1 Proteins) mRNA expression was found in COPD (show ARCN1 Proteins) patients.
Defective sirtuin-1 was found to increase IL-4 (show IL4 Proteins) expression through acetylation of GATA-3 (show GATA3 Proteins) in patients with severe asthma compared with healthy controls.
SIRT1 gene polymorphisms can have direct and indirect effects on the pathogenesis of coronary artery diseases.
miR (show MLXIP Proteins)-146 exerted protective functions might be via up-regulation of Sirt1 thereby blocking NF-kappaB (show NFKB1 Proteins) and Notch (show NOTCH1 Proteins) pathways.
results suggested that SIRT1 deficiency in Bladder cancer cells could suppress cell viability by activating antioxidant response and inducing cell cycle arrest possibly via FOXO3a (show FOXO3 Proteins)-related pathways.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.
CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.
This is the first study demonstrating a role for AMPK (show PRKAA1 Proteins)-SIRT1-FOXO1 (show FOXO1 Proteins) signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1