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Polymorphism of delta3,5-delta2,4-dienoyl-coenzyme A isomerase (the ECH1 gene product protein) in human striated (show NSDHL Proteins) muscle tissue
Possible roles for the ECH1 protein product in peroxisomal beta-oxidation are discussed.
current work indicates the involvement of Ech1 in tumor metastasis development and progression, but the subcellular location of Ech1 has not much contribution to that.
Down-regulation of Ech1 can inhibit the adhesive capacity of metastatic Hca-F cells.
Down-regulation of ECH1 could inhibit the cell proliferation and migration of Hca-F hepatocarcinoma cells.
The downregulation of Ech1 inhibited proliferation of the Hca-F cells, increased the ratio of Hca-F cells in S phase to G(1) phase and decreased the adhesion and migration capacities of Hca-F cells.
disruption of peroxisomal fatty acid beta-oxidation at the level of enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase (L-PBE) in mice leads to the induction of many of the PPARalpha (show PPARA Proteins) target genes independently of peroxisome proliferation in hepatocytes
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
enoyl Coenzyme A hydratase 1, peroxisomal
, delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
, peroxisomal enoyl-coenzyme A hydratase-like protein
, delta3,5-delta2,4-dienoyl-CoA isomerase
, dienoyl-CoA isomerase
, peroxisomal enoyl-CoA hydratase 1
, peroxisomal enoyl coenzyme A hydratase 1
, ECH1-like protein
, Peroxisomal enoyl hydratase-like protein
, enoyl coenzyme A hydratase 1, peroxisomal
, enoyl hydratase-like protein peroxisomal
, enoyl hydratase-like protein, peroxisomal
, peroxisomal/mitochondrial dienoyl-CoA isomerase