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Polymorphism of delta3,5-delta2,4-dienoyl-coenzyme A isomerase (the ECH1 gene product protein) in human striated (show NSDHL Proteins) muscle tissue
Possible roles for the ECH1 protein product in peroxisomal beta-oxidation are discussed.
Ech1 protects against high-fat-diet-induced hepatic steatosis and insulin (show INS Proteins) resistance.
current work indicates the involvement of Ech1 in tumor metastasis development and progression, but the subcellular location of Ech1 has not much contribution to that.
Down-regulation of Ech1 can inhibit the adhesive capacity of metastatic Hca-F cells.
Down-regulation of ECH1 could inhibit the cell proliferation and migration of Hca-F hepatocarcinoma cells.
The downregulation of Ech1 inhibited proliferation of the Hca-F cells, increased the ratio of Hca-F cells in S phase to G(1) phase and decreased the adhesion and migration capacities of Hca-F cells.
disruption of peroxisomal fatty acid beta-oxidation at the level of enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase (L-PBE) in mice leads to the induction of many of the PPARalpha (show PPARA Proteins) target genes independently of peroxisome proliferation in hepatocytes
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
enoyl Coenzyme A hydratase 1, peroxisomal
, delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
, peroxisomal enoyl-coenzyme A hydratase-like protein
, delta3,5-delta2,4-dienoyl-CoA isomerase
, dienoyl-CoA isomerase
, peroxisomal enoyl-CoA hydratase 1
, peroxisomal enoyl coenzyme A hydratase 1
, ECH1-like protein
, Peroxisomal enoyl hydratase-like protein
, enoyl coenzyme A hydratase 1, peroxisomal
, enoyl hydratase-like protein peroxisomal
, enoyl hydratase-like protein, peroxisomal
, peroxisomal/mitochondrial dienoyl-CoA isomerase