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This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
enoyl Coenzyme A hydratase 1, peroxisomal
, delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
, peroxisomal enoyl-coenzyme A hydratase-like protein
, delta3,5-delta2,4-dienoyl-CoA isomerase
, dienoyl-CoA isomerase
, peroxisomal enoyl-CoA hydratase 1
, peroxisomal enoyl coenzyme A hydratase 1
, ECH1-like protein
, Peroxisomal enoyl hydratase-like protein
, enoyl coenzyme A hydratase 1, peroxisomal
, enoyl hydratase-like protein peroxisomal
, enoyl hydratase-like protein, peroxisomal
, peroxisomal/mitochondrial dienoyl-CoA isomerase