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anti-Human WWP2 Antibodies:
anti-Mouse (Murine) WWP2 Antibodies:
anti-Rat (Rattus) WWP2 Antibodies:
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Cow (Bovine) Polyclonal WWP2 Primary Antibody for IHC, WB - ABIN2774931
Rougier, van Bemmelen, Bruce, Jespersen, Gavillet, Apothéloz, Cordonier, Staub, Rotin, Abriel: Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. in American journal of physiology. Cell physiology 2005
Describe an autoinhibitory mechanism for WWP2 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
results provide evidence that WWP2 serves as a positive regulator of osteogenesis by augmenting RUNX2 (show RUNX2 Antibodies) transactivation in a non-proteolytic mono-ubiquitination manner.
Data suggest that elevated expression of WW domain containing E3 ubiquitin protein ligase 2 (WWP2) may play a role in facilitating the development of lung adenocarcinoma.
we demonstrate that WWP2 promotes cell adhesion, invasion, and migration in liver cancer by upregulating CXCR3 (show CXCR3 Antibodies) and CCR5 expression associated with the chemokine (show CCL1 Antibodies) signaling pathway.
WWP2 may represent a novel diagnostic marker and molecular therapeutic target for liver cancer.
majority of ovarian carcinomas harbored homozygous or heterozygous deletions in WWP2 locus, and there was an inverse correlation in the expression levels between WWP2 and Notch3 (show NOTCH3 Antibodies) in ovarian carcinomas
Data provide evidence that the stability of Paip1 (show PAIP1 Antibodies) can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation.
Results identify WWP2 as a novel p73 (show TP73 Antibodies)-associated protein that ubiquitinates and degrades p73 (show TP73 Antibodies).
Wwp2 acts as a ubiquitin ligase of SRG3 (show SMARCC1 Antibodies).
WWP2-N is downregulated in stage IIIC melanoma and up-regulated in stage II/III prostate cancer, and WWP2-FL and WWP2-C overexpression is associated with early-stage breast cancer.
Wwp2 acts as a ubiquitin ligase (show RNF123 Antibodies) of SRG3 (show SMARCC1 Antibodies).
WWP2 negatively regulates TLR3 (show TLR3 Antibodies)-mediated innate immune and inflammatory responses by targeting TRIF (show RNF138 Antibodies) for ubiquitination and degradation.
a number of miR (show MLXIP Antibodies)-25 candidate gene targets
Data show that MiR (show MLXIP Antibodies)-140 is co-expressed with Wwp2-C and is activated by Sox9 (show SOX9 Antibodies) to target Sp1 (show SP1 Antibodies) in maintaining chondrocyte proliferation.
ADAR2 (show ADARB1 Antibodies) protein levels and catalytic activity are coordinately regulated in a positive manner by Pin1 (show PIN1 Antibodies) and negatively by WWP2 and this may have downstream effects on the function of glutamate receptor 2 (show GRIA2 Antibodies).
The regulatory interaction between Sox9 (show SOX9 Antibodies), Wwp2 and Med25 (show MED25 Antibodies) defines the Sox9 (show SOX9 Antibodies) transcriptional mechanisms of chondrogenesis in the forming palate.
Studies demonstrate that Wwp2 influences craniofacial patterning through its interactions with Goosecoid (Gsc (show GSC Antibodies)).
Wwp2-mediated Oct4 (show POU5F1 Antibodies) poly-ubiquitination and its auto-ubiquitination occur through the Lys (show LYZ Antibodies) 63 linkage and may be involved in down-regulation of Oct4 (show POU5F1 Antibodies) protein levels.
These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.
NEDD4-like E3 ubiquitin-protein ligase WWP2
, WW domain-containing protein 2
, WW domain containing E3 ubiquitin protein ligase 2
, atrophin-1 interacting protein 2
, WW domain-containing protein 4