anti-Mouse (Murine) TRKA antibody for Immunofluorescence

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
  • Trk
  • C80751
  • Tkr
  • TrkA
  • trk
  • trka
  • CTRKA
  • trkA
  • neurotrophic receptor tyrosine kinase 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • Ntrk1
  • ntrk1
Reactivity
Human, Mouse (Murine)
426
259
206
2
2
Host
Rabbit
399
52
4
3
2
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
17
16
16
10
9
8
8
8
7
7
7
7
7
7
7
7
6
2
2
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Western Blotting (WB)
276
169
123
88
59
51
47
40
19
11
9
5
4
2
1
1
1
Supplier
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Catalog No. ABIN3031990
$ 452.38
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
13.075204 ABIN3183034 ELISA IF Rabbit IgG pTyr496 Log in to see Polyclonal 0
10 ABIN5531716 FACS IF WB Rabbit Ig Fraction Log in to see Polyclonal 0
8.587764 ABIN1531406 IF ELISA Rabbit IgG AA 471-520, pTyr496 Log in to see Polyclonal 0
7 ABIN652382 FACS IF WB Rabbit Ig Fraction Log in to see Polyclonal 0
6.438406 ABIN5947442 FACS ICC IF IHC IHC (p) IP WB Rabbit IgG AA 750-850 Log in to see SU0354 0
3.438406 ABIN5947441 ICC IF IHC IHC (p) WB Rabbit IgG C-Term Log in to see JJ084-04 0
1 ABIN2755760 IC IF IHC WB Rabbit pTyr496 Log in to see Polyclonal 0
1 ABIN2884444 ELISA IF Rabbit IgG pTyr496 Log in to see Polyclonal 0
1 ABIN1808770 FACS IF WB Rabbit Log in to see Polyclonal 0
1 ABIN1003520 IF IP WB Rabbit phosphospecific Log in to see Polyclonal 0

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Reactivity Human, Mouse (Murine)
(426), (259), (206), (2), (2)
Host Rabbit
(399), (52), (4), (3), (2)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(17), (16), (16), (10), (9), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (6), (2), (2), (1), (1), (1)
Application Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(276), (169), (123), (88), (59), (51), (47), (40), (19), (11), (9), (5), (4), (2), (1), (1), (1)
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Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling Images
Purification Purified
Immunogen This TrkA antibody was produced from rabbits immunized with TrkA his fusion protein
Isotype Ig Fraction
Plasmids, Primers & others

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling Images back to top
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background TrkA is a receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. [UniProt]
UniProt P04629
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling Images back to top
Application Notes Titration of the TrkA antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details Images back to top
Format Liquid
Buffer In 1X PBS,  pH 7.4, with 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Aliquot the TrkA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling back to top
Supplier Images
Immunofluorescence (IF) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody (ABIN3031990) Confocal immunofluorescent analysis of TrkA antibody with MDA-MB231 cells followed by...
Flow Cytometry (FACS) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody (ABIN3031990) TrkA antibody flow cytometric analysis of WiDr cells (green) compared to a negative c...
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody (ABIN3031990) Western blot analysis of TrkA antibody and mouse brain tissue lysate. Observed molecu...