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|Antigen||Insulin (INS) Antibodies|
|Reactivity||Human, Rabbit, Rat (Rattus) Alternatives|
|Conjugate||This Insulin antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|20 references available|
Product Details anti-Insulin AntibodyTarget Details Insulin Application Details Handling References for anti-Insulin antibody (ABIN3043651) Images
|Purpose||Mouse IgG monoclonal antibody for Insulin, insulin (INS) detection. Tested with IHC-P in Human,rabbit,rat. No cross reactivity with other proteins.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Mouse IgG monoclonal antibody for Insulin, insulin (INS) detection. Tested with IHC-P in Human,rabbit,rat.
Gene Name: insulin
Protein Name: Insulin
|Plasmids, Primers & others|
Target Details InsulinProduct Details anti-Insulin Antibody Application Details Handling References for anti-Insulin antibody (ABIN3043651) Images back to top
|Alternative Name||INS (INS Antibody Abstract)|
Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns, exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al.(1981) and Harper and Saunders(1981) assigned the insulin gene to 11p15.5 by in situ hybridization.
|Gene ID||3630, 16334, 24509|
|UniProt||P01308, P01326, P01323|
|Pathways||NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation|
Application DetailsProduct Details anti-Insulin Antibody Target Details Insulin Handling References for anti-Insulin antibody (ABIN3043651) Images back to top
IHC-P: Concentration: 0.4-1 μg/mL, Species: Human, rabbit, rat
Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by ABIN921230 in IHC(P).
|Restrictions||For Research Use only|
HandlingProduct Details anti-Insulin Antibody Target Details Insulin Application Details References for anti-Insulin antibody (ABIN3043651) Images back to top
|Reconstitution||Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.|
|Buffer||Mouse ascites fluid, 1.2 % sodium acetate, 2 mg BSA, with 0.01 mg Sodium azide as preservative.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
References for anti-Insulin antibody (ABIN3043651)Product Details anti-Insulin Antibody Target Details Insulin Application Details Handling Images back to top
|Product cited in:||
Liu, Raynal, Bailbé, Gausseres, Carbonne, Autier, Movassat, Kergoat, Portha: "Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity." in: Biochimica et biophysica acta, Vol. 1852, Issue 5, pp. 980-91, 2015
Liu, Gu, Zhao, An, Yang: "Glypican 4 may be involved in the adipose tissue redistribution in high-fat feeding C57BL/6J mice with peroxisome proliferators-activated receptor ? agonist rosiglitazone treatment." in: Experimental and therapeutic medicine, Vol. 8, Issue 6, pp. 1813-1818, 2014
Xu, Dong, Huang, Li, Qin, Ren, Guo, Chen, Huang: "Decreased osteoclastogenesis, osteoblastogenesis and low bone mass in a mouse model of type 2 diabetes." in: Molecular medicine reports, Vol. 10, Issue 4, pp. 1935-41, 2014
Adise, Saliu, Maldonado, Khatri, Cardoso, Rodríguez-Contreras: "Effect of maternal care on hearing onset induced by developmental changes in the auditory periphery." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 13, pp. 4528-33, 2014
Ding, Zhu, Yin, Liu, Zhang, Bernier, Zhao: "Pyrrolidine dithiocarbamate protects pancreatic ?-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats." in: Acta biochimica et biophysica Sinica, Vol. 46, Issue 7, pp. 582-9, 2014
Chen, Yang, He, Song, Liu: "Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis." in: Neural regeneration research, Vol. 8, Issue 19, pp. 1756-64, 2014
Zhang, Ye, Wang, Gao, Tan, Zhuo, Liu, Xia, Yang, Li: "Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats." in: BioMed research international, Vol. 2013, pp. 526367, 2013
Zhou, Zhou, Zeng: "Experimental diabetes treated with trigonelline: effect on ? cell and pancreatic oxidative parameters." in: Fundamental & clinical pharmacology, Vol. 27, Issue 3, pp. 279-87, 2013
Hu, Yuan, Li, Huang, Mao, Zhang, Lin, Sun, Zhong, Tang, Lu: "Anti-Diabetic Activities of Jiaotaiwan in db/db Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2013, pp. 180721, 2013
Gao, Liu, Liu, Chen, Li, Lei, Sun, Li, Liu, Shen: "A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice." in: Journal of ethnopharmacology, Vol. 151, Issue 1, pp. 675-85, 2013
Wang, Ni, Xu, Liang, Du, Gu: "Effects of long-term high-fat/high-energy and high-protein diets on insulin and ghrelin expression in developing rats." in: Endocrine research, Vol. 37, Issue 3, pp. 97-109, 2012
Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: "Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct." in: Lymphology, Vol. 44, Issue 1, pp. 21-8, 2011
Su, Meng, Sun, Liu, Su: "Intramuscular injection of soluble receptor for advanced glycation endproducts expression vector prevents the development of streptozotocin-induced diabetes mellitus in rats on high fat diet." in: Journal of diabetes, Vol. 3, Issue 4, pp. 309-16, 2011
Xu, Ke, Liang, Wang, Pei, Du: "PEG-rhGH therapy for small for gestational age rats and effects on their metabolic parameters." in: Hormone research in pædiatrics, Vol. 76, Issue 1, pp. 35-43, 2011
Zhang, Jin, Hu, Yu, Li, Ding, Kang, Wang: "Protective response against type 1 diabetes in nonobese diabetic mice after coimmunization with insulin and DNA encoding proinsulin." in: Human gene therapy, Vol. 21, Issue 2, pp. 171-8, 2010
Shen, Liu, Hou, Yang, Wu, Zhang, Li, Che, Lu, Zhang, Liu, Yao: "NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 8, pp. 1371-81, 2010
Chen, Yang, Zheng, Hu, Kong, Zhang: "Effect of catch-up growth after food restriction on the entero-insular axis in rats." in: Nutrition & metabolism, Vol. 7, pp. 45, 2010
Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: "Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats." in: Experimental biology and medicine (Maywood, N.J.), Vol. 234, Issue 5, pp. 595-603, 2009
Liang, Yin, Zhang, Zhang, Zeng, Wang, Jiang, Yuan, Wang, Li: "Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance." in: Endocrinology, Vol. 149, Issue 6, pp. 2943-51, 2008
Lu, Gu, Xu, Liu, Xie, Song: "Adult islets cultured in collagen gel transdifferentiate into duct-like cells." in: World journal of gastroenterology, Vol. 11, Issue 22, pp. 3426-30, 2005
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