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|Antigen||Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This IRAK4 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-IRAK4 AntibodyTarget Details IRAK4 Application Details Handling Images
|Specificity||This antibody recognizes IRAK4 at N-term.|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|Immunogen||Peptide with sequence from the N Terminus of the protein sequence according to NP_057207.2, NP_001107654.1. Genename: IRAK4|
Target Details IRAK4Product Details anti-IRAK4 Antibody Application Details Handling Images back to top
|Alternative Name||IRAK4 (IRAK4 Antibody Abstract)|
|Background||Interleukin 1 (IL1) and lipopolysaccharide (LPS) induces cellular responses through IL1 receptor (IL1R) and Toll like receptors (TLR). IL1R associated kinases (IRAK, IRAK2, and IRAKM) regulate the activation of NF-kB and MAP kinase (MAPK) by IL1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK4. Overexpression of IRAK4 activates NF-kB and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1. IRAK4 deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL1R/TLR mediated inflammatory responses and in innate immunity.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64|
|Research Area||Atherosclerosis, Cytokines, Immunology, Inflammation, Innate Immunity, Receptors|
|Pathways||NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-IRAK4 Antibody Target Details IRAK4 Handling Images back to top
Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IRAK4 Antibody Target Details IRAK4 Application Details Images back to top
|Buffer||Tris saline containing 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|