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|Antigen||Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies|
|Conjugate||This MAP3K7 antibody is un-conjugated Alternatives|
Dot Blot (DB), Enzyme Immunoassay (EIA)
|5 references available|
|Supplier||Log in to see|
Product Details anti-MAP3K7 AntibodyTarget Details MAP3K7 Application Details Handling References for anti-MAP3K7 antibody (ABIN358312) Images
|Specificity||This antibody detects TAK1 / MAP3K7 pSer192.|
Species reactivity (expected):Mouse (100 % Antigen Homology).
Species reactivity (tested):Human.
|Purification||Protein A Chromatography followed by two-step phosphospecific peptide affinity purification|
|Immunogen||KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Ser192 of Human MAP3K7. Genename: MAP3K7|
Target Details MAP3K7Product Details anti-MAP3K7 Antibody Application Details Handling References for anti-MAP3K7 antibody (ABIN358312) Images back to top
|Alternative Name||TAK1 / MAP3K7 (MAP3K7 Antibody Abstract)|
|Background||MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.Synonyms: Mitogen-activated protein kinase kinase kinase 7, TAK-1, TAK1, TGF-beta-activated kinase 1, Transforming growth factor-beta-activated kinase 1|
|Molecular Weight||67196 Da|
|Gene ID||6885, 9606|
|Pathways||NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-MAP3K7 Antibody Target Details MAP3K7 Handling References for anti-MAP3K7 antibody (ABIN358312) Images back to top
ELISA: 1/1,000. Dot Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details References for anti-MAP3K7 antibody (ABIN358312) Images back to top
|Buffer||PBS, 0.09 % (W/V) Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-MAP3K7 antibody (ABIN358312)Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling Images back to top
Smit, Baas, Kuipers, Korswagen, van de Wetering, Clevers: "Wnt activates the Tak1/Nemo-like kinase pathway." in: The Journal of biological chemistry, Vol. 279, Issue 17, pp. 17232-40, 2004
Ono, Ohtomo, Ninomiya-Tsuji, Tsuchiya: "A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta." in: Biochemical and biophysical research communications, Vol. 307, Issue 2, pp. 332-7, 2003
Sakurai, Suzuki, Kawasaki, Nakano, Okazaki, Chino, Doi, Saiki: "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36916-23, 2003
Cheung, Campbell, Nebreda, Cohen: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003
Edlund, Bu, Schuster, Aspenström, Heuchel, Heldin, ten Dijke, Heldin, Landström et al.: "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase ..." in: Molecular biology of the cell, Vol. 14, Issue 2, pp. 529-44, 2003
ImagesProduct Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling References for anti-MAP3K7 antibody (ABIN358312) back to top