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|Antigen||Nerve Growth Factor beta (NGFB) Antibodies|
|Reactivity||Cow (Bovine), Human, Mouse (Murine), Viper (Viperidae) Alternatives|
|Conjugate||This NGFB antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Functional Studies (Func), Immunoprecipitation (IP)
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Product Details anti-NGFB AntibodyTarget Details NGFB Application Details Handling Images
|Specificity||,Species:Human, Mouse, Bovine and Viper.|
|Characteristics||Synonyms: Beta-NGF, NGFB, Beta-nerve growth factor|
|Immunogen||Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized withhuman recombinant nerve growth factor and mouse myeloma cells.|
Target Details NGFBProduct Details anti-NGFB Antibody Application Details Handling Images back to top
|Alternative Name||NGF (NGFB Antibody Abstract)|
|Background||Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90 % homology between the two species. Recently, it has been shown that cells which do not normally respond to NGF only express low affinity receptors from transfected NGF genes but cells which normally are NGF-responsive express high affinity receptors from the same NGF sequences. This supports the hypothesis that the high affinity receptors have a unique component in addition to the subunit common to the low affinity receptors.Synonyms: Beta-NGF, Beta-nerve growth factor, NGFB|
|Pathways||NF-kappaB Signaling, RTK Signaling, Regulation of Cell Size|
Application DetailsProduct Details anti-NGFB Antibody Target Details NGFB Handling Images back to top
Suitable for EIA and Neutralizing. This antibody can be used for Immunoprecipitation. Positive Control: PC12 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NGFB Antibody Target Details NGFB Application Details Images back to top
|Buffer||PBS, 0.05 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
|Expiry Date||12 months|