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|Antigen||Nerve Growth Factor Receptor (NGFR) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This NGFR antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-NGFR AntibodyTarget Details NGFR Application Details Handling Images
|Specificity||This antibody detects CD271 / NGFR.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse|
|Purification||Peptide affinity chromatography|
|Immunogen||NGFR antibody was raised against purified recombinant human NGFR.|
Target Details NGFRProduct Details anti-NGFR Antibody Application Details Handling Images back to top
|Alternative Name||CD271 / NGFR (NGFR Antibody Abstract)|
|Background||The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family (2). Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination (reviewed in 3). Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4 (4). NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins (5). Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR (6).Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16|
|Pathways||NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding|
Application DetailsProduct Details anti-NGFR Antibody Target Details NGFR Handling Images back to top
ELISA. Western blot: 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NGFR Antibody Target Details NGFR Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|