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Dermal CD271+ cells are closely associated with wound healing.
p75NTR+ cells isolated from tongue squamous cell carcinoma (TSCC) cell lines possess the characteristics of cancer stem cells; therefore, p75NTR may be considered a useful surface marker for the identification of TSCC stem cells.
This study show evidence of variation in plasmatic p75NTR receptor expression during the progression of dementia.
p75(NTR) was overexpressed in anaplastic thyroid cancers compared with papillary and follicular subtypes
p75NTR, mainly expressed in tumor tissues, was significantly associated with higher Fuhrman grade in multivariate analysis. these data highlight for the first time an important role for p75NTR in renal cancer and indicate a putative novel target therapy in renal cell carcinoma (show MOK Proteins).
Here, the authors unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 (show TP53 Proteins) inactivator. p53 (show TP53 Proteins) activates NGFR transcription, whereas NGFR inactivates p53 (show TP53 Proteins) by promoting its MDM2 (show MDM2 Proteins)-mediated ubiquitin-dependent proteolysis and by directly binding to its central DNA binding domain and preventing its DNA-binding activity.
Data suggest that p75NTR as a central regulator of glioma tumorigenesis, the tumor microenvironment, and tumor invasiveness; p75NTR may contribute to the drug resistance of glioma. [REVIEW]
These results demonstrated that EpCAM (show EPCAM Proteins) + p75NTR+ CTC count was a more accurate diagnostic marker than EpCAM (show EPCAM Proteins)+ CTC count, suggesting the highly metastatic potential of CTCs with p75NTR expression.
Co-immunoprecipitation and biochemical fractionation data suggested that p75 (show CUX1 Proteins) TM stimulates TrkB (show NTRK2 Proteins) phosphorylation at the cell membrane.
hese results suggest that LNGFR(+)THY-1 (show THY1 Proteins)(+) cells identified following NCLC induction from ESCs (show NR2E3 Proteins)/iPSCs shared similar potentials with multipotent MSCs.
The carboxyl-terminal region of NRH is necessary and sufficient to rescue gastrulation defects and to induce filopodia formation in cells of the dorsal marginal zone.
NRH1 proteins play multiple roles in the proper expression of mesodermally expressed genes such as Xbra and Chordin (show CHRD Proteins), and to a lesser extent, of Xwnt11.
Data from murine model indicate that NGFR plays an important role in the pathogenesis and progression of oral squamous cell carcinoma via regulation of ESM1 (show ESM1 Proteins).
Results suggest that p75 regulates gene and protein expression that limits the distal atrophy after sciatic nerve injury, thereby regulating axonal growth and functional recovery.
Here the authors demonstrate a novel function for p75(NTR) in regulating proper cell cycle exit of neuronal progenitors in the developing rat and mouse external granule layer, which is stimulated by proneurotrophin-3. In the absence of p75(NTR), cerebellar granule cell progenitors continue to proliferate beyond their normal period, resulting in a larger cerebellum that persists into adulthood, with consequent motor defici
75NTR is involved in downstream signaling events that mediate BMP7 (show BMP7 Proteins)-induced dendritic growth in sympathetic neurons.
Neurotoxic effect of gp120 (show ITIH4 Proteins) is mediated by p75NTR.
We show that myelin-associated glycoprotein (show MAG Proteins) or CNS myelin, in general, inhibit rodent Schwann cell migration and induce their death via cleavage of the neurotrophin (show BDNF Proteins) receptor p75.
Peri (show POSTN Proteins)-synaptic glia uses p75NTR to clear proBDNF secreted from neurons. Glial p75NTR is essential for long term potentiation maintenance.
Neuronal death induced by p75NTR requires Cys259.
NRADD deletion results in an increase in the proportion of dorsal root ganglion neurons expressing p75NTR
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
nerve growth factor receptor (TNFR superfamily, member 16)
, nerve growth factor receptor
, tumor necrosis factor receptor superfamily member 16-like
, NGF receptor
, TNFR superfamily, member 16
, low affinity nerve growth factor receptor
, low affinity neurotrophin receptor p75NTR
, low-affinity nerve growth factor receptor
, p75 ICD
, tumor necrosis factor receptor superfamily member 16
, nerve growth factor receptor, fast
, p75 neurotrophin receptor