anti-Human FAS antibody for Flow Cytometry

Recommended FAS Antibody (supplied by: Log in to see )

Antigen
Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
  • ALPS1A
  • APO-1
  • APT1
  • CD95
  • FAS1
  • FASTM
  • TNFRSF6
  • AI196731
  • APO1
  • TNFR6
  • Tnfrsf6
  • lpr
  • Fas cell surface death receptor
  • Fas (TNF receptor superfamily member 6)
  • FAS
  • Fas
  • fas
Reactivity
Human
661
115
95
13
11
10
5
4
3
3
3
2
1
Host
Mouse
422
308
25
5
4
3
3
Clonality
Monoclonal
Conjugate
This FAS antibody is un-conjugated
74
63
51
31
16
9
7
6
5
5
5
4
4
4
4
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
352
330
202
181
97
80
79
73
52
44
21
19
12
8
7
5
5
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
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Catalog No. ABIN1106613
$ 423.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
13.362898 ABIN238438 FACS IHC (p) Mouse IgG1 Log in to see LT95 6
13.362898 ABIN492367 FACS APC Mouse IgG1 Log in to see LT95 6
13.362898 ABIN4898536 FACS Fluorescein Mouse IgG1 Log in to see DX2 2
13.362898 ABIN192280 FACS IHC (p) PE Mouse IgG1 Log in to see LT95 5
13.362898 ABIN94249 FACS IHC (p) FITC Mouse IgG1 Log in to see LT95 5
13.362898 ABIN94250 Func FACS Mouse IgM Log in to see UT-1 4
13.362898 ABIN969519 FACS ELISA WB Mouse IgG1 Log in to see 4F8D6 2
13.362898 ABIN969518 ICC FACS ELISA WB Mouse IgG1 Log in to see 4F8H6 2
13.362898 ABIN2665766 FACS Mouse IgG1 kappa Log in to see DX2 8
13.362898 ABIN2472856 FACS IP Mouse IgG1 Extracellular Domain Log in to see LOB 3-17 4
13.362898 ABIN1845668 ELISA FACS IF/ICC WB Mouse IgG1 Log in to see 0
13.362898 ABIN1845671 FACS ELISA WB Mouse IgG1 Log in to see 0
13.362898 ABIN2661155 FACS Biotin Mouse IgG1 kappa Log in to see DX2 8
13.362898 ABIN1106623 FACS PE Mouse IgG2a Log in to see B-G27 1
13.362898 ABIN1106622 FACS FITC Mouse IgG2a Log in to see B-G27 3
13.362898 ABIN1106616 EIA FACS IF WB Mouse IgG1 Log in to see 4F8H6 2
13.362898 ABIN1106617 EIA FACS WB Mouse IgG1 Log in to see 4F8D6 2
13.362898 ABIN1106620 IHC (fro) FACS Mouse IgG2a Log in to see B-G27 3
13.362898 ABIN94248 FACS IHC (p) Mouse IgG1 Log in to see LT95 5
13.362898 ABIN2659761 FACS IF IHC PE/Dazzle™ 594 Mouse IgG1 kappa Log in to see DX2 8

General

Antigen Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
Reactivity Human
(661), (115), (95), (13), (11), (10), (5), (4), (3), (3), (3), (2), (1)
Host Mouse
(422), (308), (25), (5), (4), (3), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FAS antibody is un-conjugated
(74), (63), (51), (31), (16), (9), (7), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
(352), (330), (202), (181), (97), (80), (79), (73), (52), (44), (21), (19), (12), (8), (7), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 11 references available
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Product Details anti-FAS Antibody

Target Details FAS Application Details Handling References for anti-FAS antibody (ABIN1106613) Images
Specificity This antibody reacts with Fas.
No Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein A agarose
Immunogen Recombinant human Fas
Clone ZB4
Isotype IgG1
Plasmids, Primers & others

Target Details FAS

Product Details anti-FAS Antibody Application Details Handling References for anti-FAS antibody (ABIN1106613) Images back to top
Antigen
Alternative Name CD95 / FAS (FAS Antibody Abstract)
Background It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-human Fas antibody (clone CH-11) is known as the agonistic antibody.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6
Gene ID 355
NCBI Accession NP_000034
UniProt P25445
Pathways p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-FAS Antibody Target Details FAS Handling References for anti-FAS antibody (ABIN1106613) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-FAS Antibody Target Details FAS Application Details References for anti-FAS antibody (ABIN1106613) Images back to top
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.

References for anti-FAS antibody (ABIN1106613)

Product Details anti-FAS Antibody Target Details FAS Application Details Handling Images back to top
Background publications

Schumann, Maedler, Franklin, Konrad, Størling, Böni-Schnetzler, Gjinovci, Kurrer, Gauthier, Bosco, Andres, Berney, Greter, Becher, Chervonsky, Halban, Mandrup-Poulsen, Wollheim, Donath: "The Fas pathway is involved in pancreatic beta cell secretory function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 8, pp. 2861-6, 2007

Maedler, Schumann, Sauter, Ellingsgaard, Bosco, Baertschiger, Iwakura, Oberholzer, Wollheim, Gauthier, Donath: "Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets." in: Diabetes, Vol. 55, Issue 10, pp. 2713-22, 2006

Gilhar, Yaniv, Assy, Serafimovich, Ullmann, Kalish: "Fas pulls the trigger on psoriasis." in: The American journal of pathology, Vol. 168, Issue 1, pp. 170-5, 2006

Ito, Nakazato, Xian, Yamada, Hozumi, Murakami, Ohigashi, Ikeda, Kizaki: "1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo." in: Cancer research, Vol. 65, Issue 10, pp. 4417-24, 2005

Ahmed, Ings, Pizzey, Blundell, Thrasher, Ye, Fahey, Linch, Yong: "Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model." in: Blood, Vol. 103, Issue 6, pp. 2079-87, 2004

Holler, Tardivel, Kovacsovics-Bankowski, Hertig, Gaide, Martinon, Tinel, Deperthes, Calderara, Schulthess, Engel, Schneider, Tschopp: "Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1428-40, 2003

Maedler, Spinas, Lehmann, Sergeev, Weber, Fontana, Kaiser, Donath: "Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets." in: Diabetes, Vol. 50, Issue 8, pp. 1683-90, 2001

Jiang, Wu, Sternberg, Jones: "Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells." in: Investigative ophthalmology & visual science, Vol. 41, Issue 3, pp. 645-55, 2000

Agrawal, Marquet, Delfau-Larue, Copie-Bergman, Jouault, Reyes, Bensussan, Farcet: "CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs." in: The Journal of clinical investigation, Vol. 102, Issue 9, pp. 1715-23, 1998

Giordano, Stassi, De Maria, Todaro, Richiusa, Papoff, Ruberti, Bagnasco, Testi, Galluzzo: "Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis." in: Science (New York, N.Y.), Vol. 275, Issue 5302, pp. 960-3, 1997

Boirivant, Pica, DeMaria, Testi, Pallone, Strober: "Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis." in: The Journal of clinical investigation, Vol. 98, Issue 11, pp. 2616-22, 1997

Images

Product Details anti-FAS Antibody Target Details FAS Application Details Handling References for anti-FAS antibody (ABIN1106613) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (ABIN1106613) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody
Western Blotting (WB) image for anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (ABIN1106613) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (Image 2)