anti-Human FAS antibody for Immunohistochemistry (Frozen Sections)

Recommended FAS Antibody (supplied by: Log in to see )

Antigen
Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
  • AI196731
  • APO1
  • APT1
  • CD95
  • TNFR6
  • Tnfrsf6
  • lpr
  • TNFRSF6
  • ALPS1A
  • APO-1
  • FAS1
  • FASTM
  • A630082H08Rik
  • FAS
  • Fas (TNF receptor superfamily member 6)
  • Fas (TNF receptor superfamily, member 6)
  • Fas cell surface death receptor
  • fatty acid synthase
  • Fas
  • FAS
  • Fasn
Reactivity
Human
647
116
101
21
15
10
6
6
3
3
3
3
2
1
Host
Mouse
421
305
29
5
4
3
3
Clonality
Monoclonal
Conjugate
This FAS antibody is un-conjugated
73
65
51
29
15
8
8
8
6
6
6
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
349
326
211
149
113
85
60
53
52
46
25
18
12
9
7
7
6
4
4
3
3
3
3
3
2
2
2
2
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN1106610
$ 456.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1383736 IHC (fro) FACS Mouse IgG2a Log in to see B-G27 3
1 ABIN1106620 IHC (fro) FACS Mouse IgG2a Log in to see B-G27 3
1 ABIN440434 ELISA FACS IHC IHC (fro) IHC (p) IP Biotin Mouse IgG1 Log in to see DX2
1 ABIN440429 FACS ICC IHC IHC (fro) IHC (p) IP FITC Mouse IgG1 Log in to see DX2
1 ABIN440431 FACS IHC (fro) IP IHC PE Mouse IgG1 Log in to see DX2
1 ABIN440430 ELISA FACS ICC IHC IHC (fro) IHC (p) IP Biotin Mouse IgG1 Log in to see DX2
1 ABIN440433 FACS IHC IHC (fro) IHC (p) IP FITC Mouse IgG1 Log in to see DX2
1 ABIN440435 FACS IHC (fro) IP IHC PE Mouse IgG1 Log in to see DX2
1 ABIN266746 IHC (fro) IHC (p) IHC Rabbit C-Term Log in to see Polyclonal
1 ABIN1106614 Func IHC (fro) FACS Mouse IgG2a Log in to see B-G27
1 ABIN2689460 IHC (fro) FACS Mouse IgG1, kappa Log in to see DX2 2
1 ABIN371578 Func FACS IHC (fro) IP Mouse IgG1 Log in to see DX2 1
1 ABIN371584 Func FACS IHC (fro) IP Mouse IgG2a Log in to see DX3 1
1 ABIN187262 Func FACS IHC (fro) IF Mouse IgM Log in to see IPO-4
1 ABIN1383735 IHC (fro) FACS Mouse IgG2a Log in to see B-G27
1 ABIN187285 Func FACS IHC (fro) Mouse IgG1 Log in to see APO-1-1
1 ABIN600909 IHC (fro) FACS Mouse IgG2a Log in to see ICO-160
1 ABIN228066 IHC (fro) IHC (p) Mouse IgG1 C-Term Log in to see
1 ABIN2593903 IHC (fro) FACS IP Mouse IgG1 Log in to see DX2
1 ABIN2593897 IHC (fro) FACS FITC Mouse IgG1 Log in to see DX2

General

Antigen Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
Reactivity Human
(647), (116), (101), (21), (15), (10), (6), (6), (3), (3), (3), (3), (2), (1)
Host Mouse
(421), (305), (29), (5), (4), (3), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FAS antibody is un-conjugated
(73), (65), (51), (29), (15), (8), (8), (8), (6), (6), (6), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(349), (326), (211), (149), (113), (85), (60), (53), (52), (46), (25), (18), (12), (9), (7), (7), (6), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 16 references available
Supplier Log in to see

Product Details anti-FAS Antibody

Target Details FAS Application Details Handling References for anti-FAS antibody (ABIN1106610) Images
Specificity This antibody recognizes the human Fas antigen specifically.
No Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ammonium sulfate precipitation and affinity chromatography on protein A agarose
Immunogen Recombinant human Fas
Clone UB2
Isotype IgG1

Target Details FAS

Product Details anti-FAS Antibody Application Details Handling References for anti-FAS antibody (ABIN1106610) Images back to top
Antigen
Alternative Name CD95 / FAS (FAS Antibody Abstract)
Background It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumor necrosis factor receptor and nerve growth factor receptor.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6
Gene ID 355
NCBI Accession NP_000034
UniProt P25445
Pathways p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-FAS Antibody Target Details FAS Handling References for anti-FAS antibody (ABIN1106610) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-FAS Antibody Target Details FAS Application Details References for anti-FAS antibody (ABIN1106610) Images back to top
Reconstitution Prepare a stock solution by dissolving the lyophilized antibody in 100 μL of distilled water.
Buffer PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.

References for anti-FAS antibody (ABIN1106610)

Product Details anti-FAS Antibody Target Details FAS Application Details Handling Images back to top
Background publications

Vega, Jazirehi, Huerta-Yepez, Bonavida: "Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin's lymphoma cell line via inhibition of NF-kappa B activity: role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 4, pp. 2174-83, 2005

Watanabe-Fukunaga, Brannan, Copeland, Jenkins, Nagata: "Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis." in: Nature, Vol. 356, Issue 6367, pp. 314-7, 1992

Kobayashi, Hamamoto, Yamamoto, Ishii, Yonehara, Yonehara: "Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9620-4, 1991

Yonehara, Ishii, Yonehara: "A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor." in: The Journal of experimental medicine, Vol. 169, Issue 5, pp. 1747-56, 1989

Product cited in:

Mezosi, Wang, Utsugi, Bajnok, Bretz, Gauger, Thompson, Baker: "Induction and regulation of Fas-mediated apoptosis in human thyroid epithelial cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 19, Issue 3, pp. 804-11, 2005

Hauptschein, Sloan, Torella, Moezzifard, Giel-Moloney, Zehetmeier, Unger, Ilag, Jay: "Functional proteomic screen identifies a modulating role for CD44 in death receptor-mediated apoptosis." in: Cancer research, Vol. 65, Issue 5, pp. 1887-96, 2005

Suhara, Fukuo, Yasuda, Tsubakimoto, Takemura, Kawamoto, Yokoi, Mogi, Kaimoto, Ogihara: "Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways." in: Hypertension, Vol. 43, Issue 6, pp. 1208-13, 2004

Suhara, Kim, Kirshenbaum, Walsh: "Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation." in: Molecular and cellular biology, Vol. 22, Issue 2, pp. 680-91, 2001

Shinohara, Yagita, Ikawa, Oyaizu: "Fas drives cell cycle progression in glioma cells via extracellular signal-regulated kinase activation." in: Cancer research, Vol. 60, Issue 6, pp. 1766-72, 2000

Sata, Suhara, Walsh: "Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: implications for vascular disease and therapy." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 20, Issue 2, pp. 309-16, 2000

Hiromatsu, Hoshino, Yagita, Koga, Sakisaka, Honda, Yang, Kayagaki, Okumura, Nonaka: "Functional Fas ligand expression in thyrocytes from patients with Graves' disease." in: The Journal of clinical endocrinology and metabolism, Vol. 84, Issue 8, pp. 2896-902, 1999

Kuwano, Miyazaki, Hagimoto, Kawasaki, Fujita, Kunitake, Kaneko, Hara: "The involvement of Fas-Fas ligand pathway in fibrosing lung diseases." in: American journal of respiratory cell and molecular biology, Vol. 20, Issue 1, pp. 53-60, 1999

Dai, Price, Brunner, Krantz: "Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis." in: Blood, Vol. 91, Issue 4, pp. 1235-42, 1998

Ando, Hiroishi, Kaneko, Moriyama, Muto, Kayagaki, Yagita, Okumura, Imawari: "Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 11, pp. 5283-91, 1997

Boirivant, Pica, DeMaria, Testi, Pallone, Strober: "Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis." in: The Journal of clinical investigation, Vol. 98, Issue 11, pp. 2616-22, 1997

Hata, Matsuzaki, Takeya, Yoshida, Sonoki, Nagasaki, Kuribayashi, Kawano, Takatsuki: "Expression of Fas/Apo-1 (CD95) and apoptosis in tumor cells from patients with plasma cell disorders." in: Blood, Vol. 86, Issue 5, pp. 1939-45, 1995

Images

Product Details anti-FAS Antibody Target Details FAS Application Details Handling References for anti-FAS antibody (ABIN1106610) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (ABIN1106610) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody