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|Antigen||Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies|
|Epitope||AA 1-170 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This FAS antibody is un-conjugated Alternatives|
|Supplier||Log in to see|
Product Details anti-FAS AntibodyTarget Details FAS Application Details Handling Images
Rat FAS / TNFRSF6 / CD95
Has cross-reactivity in ELISA with
No cross-reactivity in ELISA with
|No Cross-Reactivity||Mouse (Murine)|
|Characteristics||This antibody was obtained from a rabbit immunized with purified, recombinant Rat FAS / TNFRSF6 / CD95 (rR FAS / TNFRSF6 / CD95, ABIN2009086 NP_631933.2, Met1-Lys170,.|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Rat FAS / TNFRSF6 / CD95 protein (ABIN2009086)|
Target Details FASProduct Details anti-FAS Antibody Application Details Handling Images back to top
|Alternative Name||FAS (FAS Antibody Abstract)|
|Background||Fas, also known as APO-1, CD95 and TNFRSF6, is a member of the tumor necrosis factor (TNF) / nerve growth factor (NGF) receptor superfamily. Fas is highly expressed on the surface of a number of cell types including epithelial cells, hepatocytes, activated mature lymphocytes and other tumor cells. This receptor contains a death domain and has been shown to play a central role in the physiological regulation of programmed cell death (PCD, apoptosis) upon ligation of Fas ligand (Fas-L). This Fas receptor has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. Multiple Fas isoforms are derived from alternative spliced transcript variants, and among which, a soluble form lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoforms.|
|Pathways||p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-FAS Antibody Target Details FAS Handling Images back to top
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat FAS. The detection limit for Rat FAS is approximately 0. 00245 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FAS Antibody Target Details FAS Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|