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General |
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Antigen | serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies |
Reactivity | Human, Mouse (Murine), Rabbit, Rat (Rattus) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This SERPINE1 antibody is un-conjugated Alternatives |
Application |
Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
Alternatives
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3 references available |
Supplier | Log in to see |
Product Details anti-SERPINE1 AntibodyTarget Details SERPINE1 Application Details Handling References for anti-SERPINE1 antibody (ABIN1108977) Images |
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Cross-Reactivity (Details) | Species reactivity (tested):Human, Mouse, Rat and Rabbit. |
Clone | MA-33H1F7 |
Isotype | IgG1 |
Target Details SERPINE1Product Details anti-SERPINE1 Antibody Application Details Handling References for anti-SERPINE1 antibody (ABIN1108977) Images back to top |
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Antigen | |
Alternative Name | SERPINE1 / PAI1 (SERPINE1 Antibody Abstract) |
Background | Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1 |
NCBI Accession | NM_000602 |
UniProt | P05121 |
Pathways | p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration |
Application DetailsProduct Details anti-SERPINE1 Antibody Target Details SERPINE1 Handling References for anti-SERPINE1 antibody (ABIN1108977) Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details References for anti-SERPINE1 antibody (ABIN1108977) Images back to top |
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Concentration | 0.1 mg/mL |
Buffer | PBS, 0.02 % Sodium Azide, 0.1 % BSA |
Preservative | Sodium azide |
Precaution of Use | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C |
Storage Comment | Store the antibody undiluted at 2-8 °C. |
References for anti-SERPINE1 antibody (ABIN1108977)Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details Handling Images back to top |
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Background publications |
Rupin, Martin, Vallez, Bonhomme, Verbeuren: "Inactivation of plasminogen activator inhibitor-1 accelerates thrombolysis of a platelet-rich thrombus in rat mesenteric arterioles." in: Thrombosis and haemostasis, Vol. 86, Issue 6, pp. 1528-31, 2002 Bijnens, Gils, Knockaert, Stassen, Declerck: "Importance of the hinge region between alpha-helix F and the main part of serpins, based upon identification of the epitope of plasminogen activator inhibitor type 1 neutralizing antibodies." in: The Journal of biological chemistry, Vol. 275, Issue 9, pp. 6375-80, 2000 Debrock, Declerck: "Neutralization of plasminogen activator inhibitor-1 inhibitory properties: identification of two different mechanisms." in: Biochimica et biophysica acta, Vol. 1337, Issue 2, pp. 257-66, 1997 |