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PDE3A Products

(phosphodiesterase 3A, cGMP-Inhibited (PDE3A))
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].

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Featured PDE3A Categories

PDE3A Antibodies

High quality antibodies with extensive validation data.

PDE3A ELISA Kits

Reliable ELISA kits for a wide range of species.

PDE3A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PDE3A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7259753
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (3)
Cat. No. ABIN518720
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7269301
Quantity 100 μL
Datasheet Datasheet

Recommended PDE3A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958531
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5674894
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5674895
Quantity 96 tests
Datasheet Datasheet

Recommended PDE3A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314458
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7408213
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3114834
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PDE3A products

Abdel-Aziz, Rifaai, Abdel-Gaber: "Possible mechanisms mediating the protective effect of cilostazol in L-arginine induced acute pancreatitis in rats: role of cGMP, cAMP, and HO-1." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 393, Issue 10, pp. 1859-1870, (2020) (PubMed).

Fields, Koschinski, Zaccolo: "Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes." in: Cellular signalling, Vol. 28, Issue 7, pp. 725-32, (2017) (PubMed).

Yang, Kirton, MacDougall, Boyle, Deuchars, Frater, Ponnambalam, Hardy, White, Calaghan, Peers, Steele: "The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway." in: Science signaling, Vol. 8, Issue 398, pp. ra101, (2016) (PubMed).

Toka, Tank, Schächterle, Aydin, Maass, Elitok, Bartels-Klein, Hollfinger, Lindschau, Mai, Boschmann, Rahn, Movsesian, Müller, Doescher, Gnoth, Mühl, Toka, Wefeld-Neuenfeld, Utz, Töpper, Jordan et al.: "Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly. ..." in: Hypertension (Dallas, Tex. : 1979), Vol. 66, Issue 4, pp. 800-8, (2015) (PubMed).

Rajagopal, Nalli, Kumar, Bhattacharya, Hu, Mahavadi, Grider, Murthy: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, (2015) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Mahavadi, Nalli, Kumar, Hu, Kuemmerle, Grider, Murthy: "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." in: American journal of physiology. Cell physiology, Vol. 307, Issue 4, pp. C402-11, (2014) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Macdougall, Agarwal, Stopford, Chu, Collins, Longster, Colyer, Harvey, Calaghan: "Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte." in: Journal of molecular and cellular cardiology, Vol. 52, Issue 2, pp. 388-400, (2012) (PubMed).

Ückert, Waldkirch, Sonnenberg, Sandner, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).

Synonyms and alternative names related to PDE3A

phosphodiesterase 3A (PDE3A), phosphodiesterase 3A, cGMP-inhibited (Pde3a), cGMP-inhibited 3',5'-cyclic phosphodiesterase A (LOC100540515), phosphodiesterase 3A (pde3a), phosphodiesterase 3A, cGMP-inhibited (pde3a), phosphodiesterase 3A, cGMP inhibited (Pde3a), phosphodiesterase 3A (Pde3a), A930022O17Rik, C87899, CGI-PDE, CGI-PDE-A, CGI-PDE A, PDE3A, Pde3a, RNPDE3A, si:dkey-48h7.2

Protein level used designations for PDE3A

  • phosphodiesterase 3A, cGMP-inhibited
  • cGMP-inhibited 3',5'-cyclic phosphodiesterase A
  • phosphodiesterase 3a
  • cGMP-inhibited 3',5'-cyclic phosphodiesterase A-like
  • CGI-PDE A
  • cGMP-inhibited phosphodiesterase
  • cyclic GMP-inhibited phosphodiesterase A
  • cyclic nucleotide phosphodiesterase
  • cAMP phosphodiesterase, myocardial cGMP-inhibited
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