Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Peptide
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- Target See all KCNQ2 products
- KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-KCNQ2 antibody (Catalog #: ARP76323_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
- Synonyms
- BFNC Peptide, BFNS1 Peptide, EBN Peptide, EBN1 Peptide, EIEE7 Peptide, ENB1 Peptide, HNSPC Peptide, KCNA11 Peptide, KV7.2 Peptide, KVEBN1 Peptide, KQT2 Peptide, Nmf134 Peptide, mKQT2.3 Peptide, mKQT2.4 Peptide, zgc:171872 Peptide, potassium voltage-gated channel subfamily Q member 2 Peptide, potassium voltage-gated channel, subfamily Q, member 2 Peptide, potassium voltage-gated channel subfamily KQT member 2 Peptide, potassium voltage-gated channel, KQT-like subfamily, member 2a Peptide, KCNQ2 Peptide, Kcnq2 Peptide, LOC100537363 Peptide, kcnq2a Peptide
- Background
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The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Protein Size: 872 - Molecular Weight
- 95 kDa
- Gene ID
- 3785
- UniProt
- O43526
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