Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) (Middle Region) Peptide
MTHFD1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all MTHFD1 products
- MTHFD1 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MTHFD1 antibody (Catalog #: ARP46147_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) peptide
MTHFD1 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MTHFD1 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1))
- Synonyms
- MTHFC Peptide, MTHFD Peptide, Tb07.27M11.970 Peptide, Dcs Peptide, E430024A07Rik Peptide, Mthfd Peptide, GB13160 Peptide, cb325 Peptide, fc29f07 Peptide, mthfd1 Peptide, wu:fc29f07 Peptide, zgc:55597 Peptide, methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Peptide, C-1-tetrahydrofolate synthase, cytoplasmic Peptide, putative C-1-tetrahydrofolate synthase, cytoplasmic Peptide, putative C-1-tetrahydrofolate synthase,cytoplasmic Peptide, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like Peptide, methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Peptide, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b Peptide, c-1-tetrahydrofolate synthase, cytoplasmic Peptide, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase L homeolog Peptide, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase Peptide, MTHFD1 Peptide, Mthfd1 Peptide, Tc00.1047053509509.20 Peptide, Tc00.1047053511741.50 Peptide, Tc00.1047053511517.60 Peptide, Tc00.1047053508207.240 Peptide, Tb927.7.1600 Peptide, LINJ_26_0310 Peptide, LBRM_26_0350 Peptide, LMJF_26_0320 Peptide, mthfd1l Peptide, LOC550749 Peptide, mthfd1b Peptide, Tsp_00651 Peptide, mthfd1.L Peptide, mthfd1 Peptide, LOC589933 Peptide, LOC100634307 Peptide
- Background
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MTHFD1 possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MTHFC, MTHFD
Protein Interaction Partner: MTHFD1,MCC,TRAF6,WDR8
Protein Size: 935 - Molecular Weight
- 101 kDa
- Gene ID
- 4522
- NCBI Accession
- NM_005956, NP_005947
- UniProt
- P11586
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