Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PHLPP1 Products

(PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))

Categories

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured PHLPP1 Categories

PHLPP1 Antibodies

High quality antibodies with extensive validation data.

Recommended PHLPP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN6145573
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7130610
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6264947
Quantity 100 μL
Datasheet Datasheet

Recommended PHLPP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6206653
Quantity 96 tests
Datasheet Datasheet

Recommended PHLPP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
  • (1)
Cat. No. ABIN2728848
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our PHLPP1 products

Dai, Zhang, Cheng, Yang, Chen, Liu, Wang, Yang, Jiang: "RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells." in: Carcinogenesis, (2018) (PubMed).

Teng, Sun, An, Hu, Liu, Ma, Han, Shi: "Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." in: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).

Fatima, Wagstaff, Loveland, Jans: "Interactome of the negative regulator of nuclear import BRCA1-binding protein 2." in: Scientific reports, Vol. 5, pp. 9459, (2015) (PubMed).

Huang, Chuang, Chou, Wang, Lee, Yang, Chiu, Kapuriya, Wang, Kulp, Chen: "Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1." in: Science signaling, Vol. 6, Issue 267, pp. ra19, (2013) (PubMed).

Lin, Lin, Wu, Ballard, Lee, Gloor, Vigers, Morales, Friedman, Skelton, Brandhuber: "An ATP-site on-off switch that restricts phosphatase accessibility of Akt." in: Science signaling, Vol. 5, Issue 223, pp. ra37, (2012) (PubMed).

Liu, Stevens, Gao: "mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6510-20, (2011) (PubMed).

Warfel, Niederst, Stevens, Brennan, Frame, Newton et al.: "Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein ..." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19777-88, (2011) (PubMed).

Liu, Yang, Bu, Liu, Ding, Li, Jia: "Cell-type-specific regulation of raft-associated Akt signaling." in: Cell death & disease, Vol. 2, pp. e145, (2011) (PubMed).

Cleveland-Donovan, Maile, Tsiaras, Tchkonia, Kirkland, Boney: "IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects." in: Endocrinology, Vol. 151, Issue 8, pp. 3752-63, (2010) (PubMed).

Mistafa, Ghalali, Kadekar, Högberg, Stenius et al.: "Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN ..." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27900-10, (2010) (PubMed).

Synonyms and alternative names related to PHLPP1

PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), PH domain and leucine rich repeat protein phosphatase 1 (phlpp1), PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), AI836256, mKIAA0606, PHLPP, Phlpp, PLEKHE1, Plekhe1, SCOP, Scop

Protein level used designations for PHLPP1

  • PH domain and leucine rich repeat protein phosphatase 1
  • PH domain leucine-rich repeat-containing protein phosphatase 1-like
  • PH domain leucine-rich repeat-containing protein phosphatase 1
  • PH domain-containing family E member 1
  • SCN circadian oscillatory protein
  • pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
  • suprachiasmatic nucleus circadian oscillatory protein
  • pleckstrin homology domain-containing family E member 1
  • Circadian Oscillatory Protein (SCOP)
  • PH domain leucine-rich repeat protein phosphatase 1
  • pleckstrin homology domain-containing family E protein 1
You are here:
Support