PHLPP2 Products
(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
Categories
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
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Featured PHLPP2 Categories
PHLPP2 Antibodies
High quality antibodies with extensive validation data.
PHLPP2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PHLPP2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (3)
Cat. No.
ABIN652395
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IHC (p), IP
Validations
- (2)
Cat. No.
ABIN962593
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN392229
Quantity
400 μL
Datasheet
Datasheet
Recommended PHLPP2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6212123
Quantity
96 tests
Datasheet
Datasheet
Recommended PHLPP2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124383
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3094545
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136302
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PHLPP2 products
: "Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection." in: Mitochondrion, Vol. 13, Issue 6, pp. 566-76, (2013) (PubMed).: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).
: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).
Synonyms and alternative names related to PHLPP2
PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2), PH domain and leucine rich repeat protein phosphatase 2 S homeolog (phlpp2.S), PH domain and leucine rich repeat protein phosphatase 2 (phlpp2), PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), AI481772, C130044A18Rik, PHLPPL, phlppl, Phlppl, RGD1562857Protein level used designations for PHLPP2
- PH domain leucine-rich repeat-containing protein phosphatase 2
- PH domain and leucine rich repeat protein phosphatase 2
- PH domain leucine-rich repeat-containing protein phosphatase 2-like
- GTPase activating protein and VPS9 domains 1
Did you look for something else?
- PHLPP1
- PHLDB3
- PHLDB2
- PHLDB1
- PHLDA3
- PHLDA2
- PHLDA1
- PHKG2
- PHKG1
- PHKB
- PHKA2
- PHKA1
- PHIP
- PHGR1
- PHGDH
- PHF8
- PHF7
- PHF6
- PHF5A
- PHF3
- PHNC2
- PHO85
- Phosducin
- Phosducin-Like
- Phosphatase and Actin Regulator 3
- Phosphatase and Actin Regulator 4
- Phosphatase and Tensin Homolog
- Phosphate Cytidylyltransferase 1, Choline, alpha
- Phosphate Cytidylyltransferase 1, Choline, beta
- Phosphate-Binding Protein PstS 1
- Phosphatidylinositol Antibody IgG/IgM
- Phosphatidylinositol Binding clathrin Assembly Protein
- Phosphatidylinositol Phosphate
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, beta
- Phospho Protein Kinase C
- Phospho-Extracellular Signal-Regulated Kinase
- PHOSPHO1
- PHOSPHO2
- Phosphodiesterase
- Phosphodiesterase I
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