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PRKAB2 Products

(Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2))

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The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq, Jul 2008].

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Featured PRKAB2 Categories

PRKAB2 Antibodies

High quality antibodies with extensive validation data.

PRKAB2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PRKAB2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (7)
Cat. No. ABIN5611226
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (4)
Cat. No. ABIN3043907
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF, IHC
Validations
  • (3)
Cat. No. ABIN7256850
Quantity 200 μL
Datasheet Datasheet

Recommended PRKAB2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3088106
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3123661
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316215
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PRKAB2 products

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Minokoshi, Alquier, Furukawa, Kim, Lee, Xue, Mu, Foufelle, Ferré, Birnbaum, Stuck, Kahn: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, (2004) (PubMed).

Park, Paulsen, Gammon, Mustard, Hardie, Winder: "Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 93, Issue 6, pp. 2081-8, (2002) (PubMed).

Prochazka, Farook, Ossowski, Wolford, Bogardus: "Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians." in: Molecular and cellular probes, Vol. 16, Issue 6, pp. 421-7, (2002) (PubMed).

Synonyms and alternative names related to PRKAB2

protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog (prkab2.L), protein kinase AMP-activated non-catalytic subunit beta 2 (PRKAB2), protein kinase, AMP-activated, beta 2 non-catalytic subunit (PRKAB2), protein kinase, AMP-activated, beta 2 non-catalytic subunit (prkab2), protein kinase, AMP-activated, beta 2 non-catalytic subunit (Prkab2), protein kinase AMP-activated non-catalytic subunit beta 2 (Prkab2), 5730553K21Rik, AW049591, BB124140, DKFZp469M1118, MGC64365, prkab2, PRKAB2

Protein level used designations for PRKAB2

  • protein kinase, AMP-activated, beta 2 non-catalytic subunit
  • AMP-activated protein kinase beta 2 non-catalytic subunit
  • 5'-AMP-activated protein kinase subunit beta-2
  • 5'-AMP-activated protein kinase, beta-2 subunit
  • AMPK beta 2
  • AMPK beta-2 chain
  • AMPK subunit beta-2
  • AMP-activated protein kinase beta-2 regulatory subunit
  • AMPK beta-2
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