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Human Interleukin 33 Protein expressed in Escherichia coli (E. coli) - ABIN1344110
Iikura, Suto, Kajiwara, Oboki, Ohno, Okayama, Saito, Galli, Nakae: IL-33 can promote survival, adhesion and cytokine production in human mast cells. in Laboratory investigation; a journal of technical methods and pathology 2007
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Human Interleukin 33 Protein expressed in Escherichia coli (E. coli) - ABIN1343983
Suzukawa, Iikura, Koketsu, Nagase, Tamura, Komiya, Nakae, Matsushima, Ohta, Yamamoto, Yamaguchi: An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 2 Pubmed References
Human Interleukin 33 Protein expressed in Escherichia coli (E. coli) - ABIN2002684
Cayrol, Girard: The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 3 Pubmed References
Data suggest that interleukin-33 (IL-33) isoforms activate basophils and mast cells to drive type 2 inflammation in chronic stable asthma.
Through induction of TF in vascular endothelial cells, IL-33 could enhance their thrombotic capacity and thereby might impact on thrombus formation in the setting of atherosclerosis.
Upregulation of GM-CSF (show CSF2 Proteins) and M-CSF (show CSF1 Proteins) production by endothelial cells, an effect that appears to be mediated by NF-kappaB (show NFKB1 Proteins) and to be independent of IL-1 (show IL1A Proteins), may be an additional mechanism through which IL-33 contributes to inflammatory activation of the vessel wall.
IL-33 could induce EMT (show ITK Proteins).
Serum IL-33 and sST2 (show SSTR2 Proteins) levels, and CD4 (show CD4 Proteins)+ST2L (show IL1RL1 Proteins)+ expression in peripheral blood mononuclear cells are closely associated with HIV-1 infection and immune reconstitution in patients received highly-active antiretroviral therapy.
IL-33 is closely interlinked in AD skins and keratinocytes. IL-33 plays an important role in the pathogenesis of immune inflammatory responses in AD, which might be a possible therapeutic target in the treatment of AD.
IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3 (show FOXA3 Proteins), and reduces FOXJmRNA.
IL-33-polymorphisms rs928413 and rs1342326 may account for an increased risk of hay (show GTF2H5 Proteins) fever with the age of 6 years
among systemic sclerosis patients in China, dyspnea was significantly associated with IL-33 rs7044343 allele frequency
Reconstitution of ST2 (show SULT2A1 Proteins) (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra (show IL1RN Proteins) though a common chain IL-1R3 (IL-1RAcP (show IL1RAP Proteins)) shared with IL-1 (show IL1A Proteins)
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (show TGFB1 Proteins) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
Our data indicate that CB2 (show CNR2 Proteins) may directly contribute to the pathogenesis of eosinophil-driven diseases. Moreover, we provide new insights into the molecular mechanisms underlying the CB2 (show CNR2 Proteins) -mediated priming of eosinophils.
IL-33 dysregulated lung Treg cells and impaired immunologic tolerance to inhaled antigens
gut (show GUSB Proteins) pericryptal fibroblasts release IL-33 to translate bacterial infection into an epithelial response to promote antimicrobial defense.
Mex-3B (show MEX3B Proteins) facilitates the development of allergic airway inflammation by directly upregulating IL-33 expression via inhibiting miR (show MLXIP Proteins)-487b-3p mediated repression of IL-33.
IL-33 promoted the new extracellular matrix deposition and angiogenesis formation, which indicates an important role of IL-33 on matrix synthesis and neovascularization.
Data indicate that interleukin-33 (IL-33)-induced Interleukin-13 (IL-13 (show IL13 Proteins)) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (show EGFR Proteins)) expression.
Heligmosomoides polygyrus Alarmin Release Inhibitor (HpARI) prevents binding of active interleukin-33 (IL-33) to the IL-33 receptor.
Despite its expression in the synovium of arthritic mice and normal keratinocytes, IL-33 is not required for collagen-induced arthritis development in arthritis or psoriasis
The studies establish chronic pancreatitis as an IL-33-dependent inflammation resulting from synergistic interactions between the NOD1 (show NOD1 Proteins) and CCKR signaling pathways.
IL-33 may be a key molecule operating in eosinophil-mediated fibrosis in high-dose-per fraction irradiated skin.
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4\; MIM 147780). IL33 is a ligand for IL33R (IL1RL1\; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010
, DVS27-related protein
, interleukin-1 family member 11
, nuclear factor for high endothelial venules
, nuclear factor from high endothelial venules