KIR2DL4/CD158d Protein (AA 22-242) (His tag)

Catalog No. ABIN1097038

Product Details

Target: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Protein Type: Recombinant

Protein Characteristics: AA 22-242

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This KIR2DL4/CD158d protein is labelled with His tag.

Purpose: Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

Sequence: WAHVGGQDKP FCSAWPSAVV PQGGHVTLRC HYRRGFNIFT LYKKDGVPVP ELYNRIFWNS FLISPVTPAH AGTYRCRGFH PHSPTEWSAP SNPLVIMVTG LYEKPSLTAR PGPTVRTGEN VTLSCSSQSS FDIYHLSREG EAHELRLPAV PSINGTFQAD FPLGPATHGE TYRCFGSFHG SPYEWSDASD PLPVSVTGNP SSSWPSPTEP SFKTGIARHL HVDHHHHHH

Characteristics: Recombinant Human Killer Cell Immunoglobulin-Like Receptor 2DL4/KIR2DL4 produced by transfected human cells is a secreted protein with sequence (Trp22-His242) of Human KIR2DL4 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Alternative Name: cd158d (KIR2DL4 Products)

Synonyms: G9P Protein, CD158D Protein, KIR103 Protein, KIR103AS Protein, KIR2DL4 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Protein, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 Protein, KIR2DL4 Protein

Sub Type: Fusionprotein

Background: Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
Alternative Names: Killer Cell Immunoglobulin-Like Receptor 2DL4, CD158 Antigen-Like Family Member D, G9P, Killer Cell Inhibitory Receptor 103AS, KIR-103AS, MHC Class I NK Cell Receptor KIR103AS, CD158d, KIR2DL4, CD158D, KIR103AS

Molecular Weight: 25.34 kDa

UniProt: Q99706