KIR2DL4/CD158d Protein (Fc Tag)
KIR2DL4
Origin: Human
Host: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
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- Target See all KIR2DL4/CD158d (KIR2DL4) Proteins
- KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This KIR2DL4/CD158d protein is labelled with Fc Tag.
- Purpose
- Human KIR2DL4 / CD158d Protein, Fc Tag
- Sequence
- His 24 - His 242
- Characteristics
- Human KIR2DL4, Fc Tag is expressed from human 293 cells (HEK293). It contains AA His 24 - His 242 (Accession # Q99706-1).
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product KIR2DL4 Protein
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Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) (AA 32-126) protein (GST tag)
KIR2DL4 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) (AA 24-242) protein (hIgG-His-tag)KIR2DL4 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 85 % by SDS - PAGE SDS
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- Application Notes
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
- Alternative Name
- KIR2DL4 / CD158d (KIR2DL4 Products)
- Synonyms
- G9P Protein, CD158D Protein, KIR103 Protein, KIR103AS Protein, KIR2DL4 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Protein, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 Protein, KIR2DL4 Protein
- Background
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Synonyms: CD158d,
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells. - Molecular Weight
- 50.5 kDa
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